Comparison · NCT04533737-deaths
Arm 1 (Brodalumab + Dummy 1) vs Arm 2 (Guselkumab + Dummy 2): deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Arm 1 (Brodalumab + Dummy 1) vs Arm 2 (Guselkumab + Dummy 2): deaths from any cause. Trial comparisons, record NCT04533737-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04533737-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0 | 0.00000000000000000694 | 0.0642 | wilson | |
| Risk in group 2 | 0 | 0.00000000000000000694 | 0.0642 | wilson | |
| Risk difference, group 1 minus group 2 | 0 | -0.0642 | 0.0642 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | log | a group has no participants with the outcome | |||
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to harm | from the risk difference interval | the two groups' risks are equal |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Arm 1 (Brodalumab + Dummy 1) | Participants receive:~* Brodalumab 210 mg (1.5 ml) at Weeks 0, 1, 2, and then every 2 weeks.~* Dummy 1 (placebo 1.0 ml) at Weeks 0, 4, and then every 8 weeks.~Brodalumab: Pre-filled syringe with 210 mg brodalumab in 1.5 ml solution for subcutaneous injection.~Placebo: The placebo solution is similar to the active guselkumab solution except that it does not contain any active substance. | 0 | 56 | EG000 |
| Group 2 | Arm 2 (Guselkumab + Dummy 2) | Participants receive:~* Guselkumab 100 mg (1.0 ml) at Weeks 0, 4, and then every 8 weeks.~* Dummy 2 (placebo 1.5 ml) at Weeks 0, 1, 2, and then every 2 weeks.~Guselkumab: Pre-filled syringe with 100 mg guselkumab in 1 ml solution for subcutaneous injection.~Placebo: The placebo solution is similar to the active brodalumab solution except that it does not contain any active substance. | 0 | 56 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- 28 Weeks
Source ClinicalTrials.gov
Trial
- Title
- Efficacy and Safety of Brodalumab Compared With Guselkumab in the Treatment of Plaque Psoriasis After Inadequate Response to Ustekinumab
- NCT number
- NCT04533737
- Phases
- PHASE4
- Conditions
- Plaque Psoriasis, Psoriasis Vulgaris, Psoriasis
- Interventions
- Brodalumab, Placebo, Guselkumab
- Lead sponsor
- LEO Pharma
- Results first posted
- 2024-01-09
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04533737?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
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GET https://conductscience.org/api/comparisons/v1/NCT04533737-deaths