Comparison · NCT04558359-deaths
Angiotensin II Cohort vs Standard of Care Cohort: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Angiotensin II Cohort vs Standard of Care Cohort: deaths from any cause. Trial comparisons, record NCT04558359-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04558359-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.5 | 0.29 | 0.71 | wilson | |
| Risk in group 2 | 0.9 | 0.596 | 0.982 | wilson | |
| Risk difference, group 1 minus group 2 | -0.4 | -0.625 | -0.0306 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.556 | 0.335 | 0.922 | log | |
| Odds ratio, group 1 over group 2 | 0.111 | 0.0116 | 1.07 | log | |
| Number needed to treat, for one fewer death from any cause on Angiotensin II Cohort than on Standard of Care Cohort | 2.5 | 1.6 | 32.7 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: standard of care.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Angiotensin II Cohort | Patients in this group will receive angiotensin II.~Angiotensin II: These patients will receive angiotensin II in addition to standard of care treatment. Plasma renin levels and biomarkers of renal function will be measured. | 9 | 18 | EG001 |
| Group 2 | Standard of Care Cohort | Patients in this group will receive standard of care treatment.~Standard of Care: These patients will receive standard of care treatment. Plasma renin levels and biomarkers of renal function will be measured. | 9 | 10 | EG000 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
Source ClinicalTrials.gov
Trial
- Title
- Renin and Renal Biomarker Response to Angiotensin II
- NCT number
- NCT04558359
- Phases
- PHASE4
- Conditions
- Septic Shock, Acute Kidney Injury
- Interventions
- Standard of Care, Angiotensin II
- Lead sponsor
- Alexander Flannery
- Results first posted
- 2024-09-04
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04558359?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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