Comparison · NCT04579393-3a9330fa
Fostamatinib With Standard of Care for Treatment of COVID-19 vs Placebo With Standard of Care for Treatment of COVID-19: Number of Participants Who Progress to Mechanical Ventilation
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Fostamatinib With Standard of Care for Treatment of COVID-19 vs Placebo With Standard of Care for Treatment of COVID-19: Number of Participants Who Progress to Mechanical Ventilation. Trial comparisons, record NCT04579393-3a9330fa. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04579393-3a9330fa
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0357 | 0.00633 | 0.177 | wilson | |
| Risk in group 2 | 0.0741 | 0.0206 | 0.234 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0384 | -0.201 | 0.113 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.482 | 0.0464 | 5.01 | log | |
| Odds ratio, group 1 over group 2 | 0.463 | 0.0395 | 5.43 | log | |
| Number needed to treat, for one fewer participant with the outcome on Fostamatinib With Standard of Care for Treatment of COVID-19 than on Placebo With Standard of Care for Treatment of COVID-19 | 26.1 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Fostamatinib With Standard of Care for Treatment of COVID-19 | Fostamatinib, will be administered orally at a dose of 150 mg twice daily for 14 days or 28 doses. | 1 | 28 | OG000 |
| Group 2 | Placebo With Standard of Care for Treatment of COVID-19 | Placebo tablets to match fostamatinib 150 mg will be provided and administered orally at a dose of 150 mg twice daily for 14 days or 28 doses. | 2 | 27 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants Who Progress to Mechanical Ventilation
- Description
- Number of participants who progress to mechanical ventilation by day 29
- Time frame
- day 29
- Population
- Participants who were not receiving mechanical ventilation at baseline
Source ClinicalTrials.gov
Trial
- Title
- Fostamatinib for Hospitalized Adults With COVID-19
- NCT number
- NCT04579393
- Phases
- PHASE2
- Conditions
- Coronavirus Disease 2019
- Interventions
- Placebo, fostamatinib
- Lead sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
- Results first posted
- 2022-03-02
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04579393?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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