Comparison · NCT04588207-7f8bc805
Urea vs No Urea: Number and Proportion of Participants Enrolled in the Study With Adverse Events Related to the Use of Urea
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Urea vs No Urea: Number and Proportion of Participants Enrolled in the Study With Adverse Events Related to the Use of Urea. Trial comparisons, record NCT04588207-7f8bc805. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04588207-7f8bc805
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.5 | 0.0945 | 0.905 | wilson | |
| Risk in group 2 | 0 | 0 | 0.658 | wilson | |
| Risk difference, group 1 minus group 2 | 0.5 | -0.273 | 0.905 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | log | a group has no participants with the outcome | |||
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat, for one more participant with the outcome on Urea than on No Urea | 2 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Urea | Participants assigned to this group will receive oral urea for 42 days | 1 | 2 | OG000 |
| Group 2 | No Urea | Participants assigned to this group will be off urea for 42 days | 0 | 2 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number and Proportion of Participants Enrolled in the Study With Adverse Events Related to the Use of Urea
- Description
- Number and proportion of participants enrolled in the study with adverse events related to the use of urea from baseline to day 42. To be assessed by medication side effect questionnaire.
- Time frame
- Baseline to day 42 while taking urea
- Population
- This measure is only relevant when on urea
Source ClinicalTrials.gov
Trial
- Title
- Urea for Chronic Hyponatremia
- NCT number
- NCT04588207
- Phases
- PHASE2
- Conditions
- Hyponatremia, Inappropriate ADH Syndrome
- Interventions
- Urea
- Lead sponsor
- Helbert Rondon Berrios, MD, MS
- Results first posted
- 2024-05-20
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04588207?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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