Comparison · NCT04615624-9fdbc16c
Furosemide vs Placebo: Number of Participants Who Required Additional Antihypertensive Agents in an Hour After Allocation
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Furosemide vs Placebo: Number of Participants Who Required Additional Antihypertensive Agents in an Hour After Allocation. Trial comparisons, record NCT04615624-9fdbc16c. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04615624-9fdbc16c
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.273 | 0.151 | 0.442 | wilson | |
| Risk in group 2 | 0.219 | 0.11 | 0.388 | wilson | |
| Risk difference, group 1 minus group 2 | 0.054 | -0.154 | 0.255 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.25 | 0.528 | 2.95 | log | |
| Odds ratio, group 1 over group 2 | 1.34 | 0.43 | 4.17 | log | |
| Number needed to treat, for one more participant with the outcome on Furosemide than on Placebo | 18.5 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Furosemide | When patient meets inclusion criteria and is randomized to treatment drug, she receives 40mg /4 milliliters (mL) IV furosemide in addition to usual antihypertensive.~Furosemide: Furosemide, a loop diuretic | 9 | 33 | OG000 |
| Group 2 | Placebo | When patient meets inclusion criteria and is randomized to placebo, she receives one dose of 4mL normal saline in addition to usual antihypertensive.~Placebo: Normal saline | 7 | 32 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- OTHER_PRE_SPECIFIED
- Title
- Number of Participants Who Required Additional Antihypertensive Agents in an Hour After Allocation
- Description
- Were any additional antihypertensive agents in hour after allocation
- Time frame
- Assessed from 0 minutes to 1 hour post-dose, 1-hour post-dose reported
- Population
Source ClinicalTrials.gov
Trial
- Title
- Furosemide vs. Placebo for Severe Antepartum Hypertension
- NCT number
- NCT04615624
- Phases
- PHASE3
- Conditions
- Pre-Eclampsia, Hypertension in Pregnancy, Pregnancy Complications, Hypertension, Pregnancy-Induced
- Interventions
- Furosemide, Placebo
- Lead sponsor
- Melanie Maykin, MD
- Results first posted
- 2024-04-18
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04615624?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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