Comparison · NCT04668209-deaths
Silmitasertib (CX-4945) in Combination With Standard of Care vs Standard of Care: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Silmitasertib (CX-4945) in Combination With Standard of Care vs Standard of Care: deaths from any cause. Trial comparisons, record NCT04668209-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04668209-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.133 | 0.0374 | 0.379 | wilson | |
| Risk in group 2 | 0.143 | 0.0401 | 0.399 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00952 | -0.283 | 0.257 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.933 | 0.151 | 5.76 | log | |
| Odds ratio, group 1 over group 2 | 0.923 | 0.112 | 7.62 | log | |
| Number needed to treat, for one fewer death from any cause on Silmitasertib (CX-4945) in Combination With Standard of Care than on Standard of Care | 105 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: standard of care.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Silmitasertib (CX-4945) in Combination With Standard of Care | Standard of care / supportive care in combination with Silmitasertib (CX-4945)~Participants received Silmitasertib (CX-4945) 1000 mg tablets orally twice a day for 14 days. Participants received supportive care/Standard of Care as assigned by the investigator. | 2 | 15 | EG000 |
| Group 2 | Standard of Care | Standard of care / supportive care~Participants received supportive care/Standard of Care. | 2 | 14 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- Day 60.
Source ClinicalTrials.gov
Trial
- Title
- Silmitasertib (CX-4945) in Patients With Severe Coronavirus Disease 2019 (COVID-19)
- NCT number
- NCT04668209
- Phases
- PHASE2
- Conditions
- Coronavirus
- Interventions
- Silmitasertib
- Lead sponsor
- University of Arizona
- Results first posted
- 2023-08-14
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04668209?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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