Comparison · NCT04679389-1c694738
Acetazolamide vs Placebo: Electrolyte Balance Testing
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Acetazolamide vs Placebo: Electrolyte Balance Testing. Trial comparisons, record NCT04679389-1c694738. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04679389-1c694738
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0 | 0 | 0.228 | wilson | |
| Risk in group 2 | 0.0833 | 0.0149 | 0.354 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0833 | -0.354 | 0.155 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | log | a group has no participants with the outcome | |||
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat, for one fewer participant with the outcome on Acetazolamide than on Placebo | 12 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Acetazolamide | Acetazolamide was administered via capsule or liquid suspension. Capsule was 250 mg oral capsules encapsulated by gelatin capsule and filled with lactose to match placebo. Liquid suspension was 25 mg/mL oral suspension but adding 125 mg Acetazolamide tablets to suspending agent Ora-blend~Acetazolamide: administered orally or enterally | 0 | 13 | OG000 |
| Group 2 | Placebo | Placebo was administered via capsule or liquid suspension. Capsule was a gelatin capsule filled with lactose powder to match Acetazolamide. Liquid suspension was a Ora-blend.~Placebo: administered orally or enterally | 1 | 12 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Electrolyte Balance Testing
- Description
Electrolyte balance was assessed through combination testing on concentration of potassium, sodium, chloride, bicarbonate, magnesium, calcium, and phosphate. The number of participants who experience a drug related adverse event related to abnormal electrolyte balance.
- Time frame
- through study completion, approximately 2 years
- Population
Source ClinicalTrials.gov
Trial
- Title
- Acetazolamide Efficacy in Ataxia in PMM2-CDG
- NCT number
- NCT04679389
- Phases
- PHASE2, PHASE3
- Conditions
- Pmm2-CDG, CDG1A
- Interventions
- Placebo, Acetazolamide
- Lead sponsor
- Mayo Clinic
- Results first posted
- 2025-03-20
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04679389?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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