Comparison · NCT04704869-e4124f7c
Early Cryoprecipitate + Massive Transfusion Protocol (RBCs, Plasma, Platelets, Whole Blood) vs Massive Transfusion Protocol (RBCs, Plasma, Platelets, Whole Blood): Death From Bleeding at 24 Hours
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Early Cryoprecipitate + Massive Transfusion Protocol (RBCs, Plasma, Platelets, Whole Blood) vs Massive Transfusion Protocol (RBCs, Plasma, Platelets, Whole Blood): Death From Bleeding at 24 Hours. Trial comparisons, record NCT04704869-e4124f7c. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04704869-e4124f7c
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0549 | 0.041 | 0.0732 | wilson | |
| Risk in group 2 | 0.0491 | 0.0361 | 0.0664 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0058 | -0.0164 | 0.0282 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.12 | 0.733 | 1.71 | log | |
| Odds ratio, group 1 over group 2 | 1.12 | 0.721 | 1.76 | log | |
Number needed to treat, for one more participant with the outcome on Early Cryoprecipitate + Massive Transfusion Protocol (RBCs, Plasma, Platelets, Whole Blood) than on Massive Transfusion Protocol (RBCs, Plasma, Platelets, Whole Blood) | 172 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Early Cryoprecipitate + Massive Transfusion Protocol (RBCs, Plasma, Platelets, Whole Blood) | Cryoprecipitate will be given in addition to the standard of care massive transfusion protocol products, which include red blood cells, plasma, platelets and whole blood. The Cryoprecipitate will be given with 90 minutes of emergency department arrival. Cryoprecipitate dose will be 3 pools (equivalent to 15 single units).~Cryoprecipitate: Cryoprecipitate is a blood product high in fibrinogen. The Cryoprecipitate will be given with 90 minutes of emergency department arrival. Cryoprecipitate dose will be 3 pools (equivalent to 15 single units).~Red Blood Cells: RBCs are utilized as part of the Massive Transfusion protocol for hemorrhage control.~Plasma: Plasma is utilized as part of the Massive Transfusion protocol for hemorrhage control.~Platelets: Platelets are utilized as part of the Massive Transfusion protocol for hemorrhage control.~Whole Blood: Whole Blood is utilized as part of the Massive Transfusion protocol for hemorrhage control. | 43 | 783 | OG000 |
| Group 2 | Massive Transfusion Protocol (RBCs, Plasma, Platelets, Whole Blood) | Only standard of care massive transfusion protocol products will be given, including red blood cells, plasma, platelets, and whole blood.~Red Blood Cells: RBCs are utilized as part of the Massive Transfusion protocol for hemorrhage control.~Plasma: Plasma is utilized as part of the Massive Transfusion protocol for hemorrhage control.~Platelets: Platelets are utilized as part of the Massive Transfusion protocol for hemorrhage control.~Whole Blood: Whole Blood is utilized as part of the Massive Transfusion protocol for hemorrhage control. | 39 | 794 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Death From Bleeding at 24 Hours
- Description
- Death related to exsanguination
- Time frame
- 24 hours after ED admission
- Population
Data were not collected from 11 participants in the Massive Transfusion Protocol (RBCs, Plasma, Platelets, Whole Blood) arm. Data were not collected from 16 participants in the Early Cryoprecipitate + Massive Transfusion Protocol (RBCs, Plasma, Platelets, Whole Blood) arm.
Source ClinicalTrials.gov
Trial
- Title
- Early Use of Cryoprecipitate With Major Hemorrhage Protocol (MHP) Activation
- NCT number
- NCT04704869
- Phases
- PHASE3
- Conditions
- Trauma Injury
- Interventions
- Cryoprecipitate, Red Blood Cells, Plasma, Platelets, Whole Blood
- Lead sponsor
- Bryan Cotton
- Results first posted
- 2023-02-21
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04704869?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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