Comparison · NCT04706507-90ac7204
IV Ganciclovir vs Placebo: To Evaluate Whether Mortality and Time to Death in the 180 Days is Different Among Ganciclovir Recipients Relative to Placebo Recipients, Respectively.
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. IV Ganciclovir vs Placebo: To Evaluate Whether Mortality and Time to Death in the 180 Days is Different Among Ganciclovir Recipients Relative to Placebo Recipients, Respectively. Trial comparisons, record NCT04706507-90ac7204. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04706507-90ac7204
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.425 | 0.335 | 0.52 | wilson | |
| Risk in group 2 | 0.222 | 0.152 | 0.314 | wilson | |
| Risk difference, group 1 minus group 2 | 0.202 | 0.0742 | 0.321 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.91 | 1.24 | 2.94 | log | |
| Odds ratio, group 1 over group 2 | 2.58 | 1.4 | 4.75 | log | |
| Number needed to treat, for one more participant with the outcome on IV Ganciclovir than on Placebo | 4.94 | 3.12 | 13.5 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | IV Ganciclovir | 5mg/kg IV twice daily for 5 days, then followed by IV ganciclovir once daily until hospital discharge | 45 | 106 | OG000 |
| Group 2 | Placebo | normal saline IV twice daily for 5 days, then followed by IV normal saline once daily until hospital discharge | 22 | 99 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- To Evaluate Whether Mortality and Time to Death in the 180 Days is Different Among Ganciclovir Recipients Relative to Placebo Recipients, Respectively.
- Description
- This is a time to event outcome with death as the event and censoring at the time of study termination if the participant is alive at the end of the study (day 180).
- Time frame
- at the final study visit (day 180)
- Population
- Includes all participant enrolled, eligible, and evaluable (not replaced).
Source ClinicalTrials.gov
Trial
- Title
- Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients With Acute Respiratory Failure and Sepsis
- NCT number
- NCT04706507
- Phases
- PHASE3
- Conditions
- Acute Respiratory Failure
- Interventions
- IV Ganciclovir, Normal saline
- Lead sponsor
- Fred Hutchinson Cancer Center
- Results first posted
- 2025-12-12
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04706507?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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