Comparison · NCT04739306-e156e43a
CT-P42 vs Eylea: Proportion of Subjects Who Gained ≥15 Letters in BCVA as Measured by ETDRS Letter Score Compared With Baseline at Week 52
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. CT-P42 vs Eylea: Proportion of Subjects Who Gained ≥15 Letters in BCVA as Measured by ETDRS Letter Score Compared With Baseline at Week 52. Trial comparisons, record NCT04739306-e156e43a. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04739306-e156e43a
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.347 | 0.28 | 0.42 | wilson | |
| Risk in group 2 | 0.297 | 0.234 | 0.369 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0497 | -0.0482 | 0.146 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.17 | 0.859 | 1.59 | log | |
| Odds ratio, group 1 over group 2 | 1.26 | 0.8 | 1.97 | log | |
| Number needed to treat, for one more participant with the outcome on CT-P42 than on Eylea | 20.1 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | CT-P42 | Subjects received Intravitreal injection of CT-P42 (2mg/0.05 mL), every 4 weeks for 5 doses, then every 8 weeks for 4 doses up to Week 48. | 60 | 173 | OG000 |
| Group 2 | Eylea | Subjects received Intravitreal injection of Eylea (2mg/0.05 mL), every 4 weeks for 5 doses, then every 8 weeks for 4 doses up to Week 48. | 52 | 175 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Proportion of Subjects Who Gained ≥15 Letters in BCVA as Measured by ETDRS Letter Score Compared With Baseline at Week 52
- Description
- Proportion of subjects who gained ≥15 letters from baseline in BCVA, assessed in change from baseline in ETDRS letters over time
- Time frame
- Baseline and Week 52
- Population
- Full analysis set. Missing data were not imputed unless methods for handling missing data are specified.
Source ClinicalTrials.gov
Trial
- Title
- Study to Compare Efficacy and Safety of CT-P42 in Comparison With Eylea in Patients With Diabetic Macular Edema
- NCT number
- NCT04739306
- Phases
- PHASE3
- Conditions
- Diabetic Macular Edema (DME)
- Interventions
- CT-P42, Eylea
- Lead sponsor
- Celltrion
- Results first posted
- 2023-12-05
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04739306?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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