Comparison · NCT04742283-sae
Timolol Maleate Opthalmic Solution 0.5% BID vs DE-126 Opthalmic Solution 0.002% QD and Vehicle QD: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Timolol Maleate Opthalmic Solution 0.5% BID vs DE-126 Opthalmic Solution 0.002% QD and Vehicle QD: serious adverse events. Trial comparisons, record NCT04742283-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04742283-sae
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0188 | 0.0064 | 0.0537 | wilson | |
| Risk in group 2 | 0.00621 | 0.0011 | 0.0343 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0125 | -0.0182 | 0.0478 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 3.02 | 0.317 | 28.7 | log | |
| Odds ratio, group 1 over group 2 | 3.06 | 0.315 | 29.7 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Timolol Maleate Opthalmic Solution 0.5% BID than on DE-126 Opthalmic Solution 0.002% QD and Vehicle QD | 79.8 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Timolol Maleate Opthalmic Solution 0.5% BID | Timolol Maleate Ophthalmic Solution 0.5% is administered twice daily (BID)~Timolol Maleate Ophthalmic Solution 0.5% BID: Timolol Maleate Ophthalmic Solution BID (morning and evening) | 3 | 160 | EG000 |
| Group 2 | DE-126 Opthalmic Solution 0.002% QD and Vehicle QD | DE-126 Ophthalmic Solution 0.002% is administered once daily (QD)~DE-126 Ophthalmic Solution 0.002% QD: DE-126 Ophthalmic Solution QD evening and Vehicle QD Morning | 1 | 161 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- From informed consent to until subject withdrawal or study exit at month 3 including two weeks of follow up after last study drug administration.
Source ClinicalTrials.gov
Trial
- Title
Multicenter Study Assessing the Efficacy and Safety of DE-126 Ophthalmic Solution 0.002% Compared With Timolol Maleate Ophthalmic Solution 0.5% in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension
- NCT number
- NCT04742283
- Phases
- PHASE2
- Conditions
- Primary Open Angle Glaucoma, Ocular Hypertension
- Interventions
- DE-126 Ophthalmic Solution 0.002% QD, Timolol Maleate Ophthalmic Solution 0.5% BID
- Lead sponsor
- Santen Inc.
- Results first posted
- 2023-01-26
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04742283?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT04742283-sae