Point of Care vs Direct Patient Engagement: Rates of Screening
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.191 | 0.188 | 0.195 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.0868 | 0.0842 | 0.0895 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | 0.105 | 0.1 | 0.109 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 2.2 | 2.13 | 2.28 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 2.49 | 2.39 | 2.59 | log | ClinicalTrials.gov | |
| Number needed to treat, for one more participant with the outcome on Point of Care than on Direct Patient Engagement | 9.56 | 9.19 | 9.97 | from the risk difference interval | ClinicalTrials.gov |
Groups 2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | Point of Care | Clinics in the point of care (POC) arm approached patients at the time they came in to the clinic for a routine visit with their primary care provider. The familial cancer risk screening was completed using electronic tablets in the waiting room or, in the case of a telehealth visit, through telephone contact before the visit. Patients identified as likely to benefit based on their risk profile, were offered genetic testing for a panel of hereditary cancers. | 9,892 | 51,693 | OG000 | ClinicalTrials.gov |
| Group 2 | Direct Patient Engagement | Clinics in the direct patient engagement (DPE) arm contacted patients by postal mail and email to provide a link to the online familial cancer risk screening tool. This occurred one to three months after the patient had a routine visit with their primary care provider. Patients identified as likely to benefit based on their risk profile, were offered genetic testing for a panel of hereditary cancers. | 3,813 | 43,930 | OG001 | ClinicalTrials.gov |
Outcome 5
| Field | Value | Source |
|---|---|---|
| Type | PRIMARY | ClinicalTrials.gov |
| Title | Rates of Screening | ClinicalTrials.gov |
| Description | Fraction of the active clinic patient population that completed screening | ClinicalTrials.gov |
| Time frame | 1 year | ClinicalTrials.gov |
| Population | Patients 25 years of age or older, comfortable speaking English, who had an appointment at one of the participating clinics during the 12 month recruitment window. | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | Early Detection of GEnetic Risk (EDGE) | ClinicalTrials.gov |
| NCT number | NCT04746794 | ClinicalTrials.gov |
| Phases | NA | ClinicalTrials.gov |
| Conditions | Genetic Predisposition | ClinicalTrials.gov |
| Interventions | Population-level screening | ClinicalTrials.gov |
| Lead sponsor | University of Washington | ClinicalTrials.gov |
| Results first posted | 2024-10-09 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT04746794?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.