Comparison · NCT04789330-66f1102e
Norepinephrine vs Phenylephrine: Number of Participants With Severe Acute Kidney Injury
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Norepinephrine vs Phenylephrine: Number of Participants With Severe Acute Kidney Injury. Trial comparisons, record NCT04789330-66f1102e. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04789330-66f1102e
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0155 | 0.0107 | 0.0223 | wilson | |
| Risk in group 2 | 0.0171 | 0.012 | 0.0241 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00158 | -0.0101 | 0.00687 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.907 | 0.547 | 1.51 | log | |
| Odds ratio, group 1 over group 2 | 0.906 | 0.541 | 1.52 | log | |
| Number needed to treat, for one fewer participant with the outcome on Norepinephrine than on Phenylephrine | 632 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Norepinephrine | Norepinephrine continuous infusion as the first line vasopressor~Norepinephrine: Norepinephrine administered during anesthesia | 28 | 1,809 | OG000 |
| Group 2 | Phenylephrine | Phenylephrine continuous infusion as the first line vasopressor~Phenylephrine: Phenylephrine administered during anesthesia | 31 | 1,817 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Severe Acute Kidney Injury
- Description
Severe acute kidney injury is assessed using the KDIGO definition based on serum creatinine or need for Renal Replacement Therapy (RRT). Severe Acute Kidney Injury is defined as an increase in serum creatinine ≥ 2-fold from baseline within 7 days, or initiation of renal replacement therapy within 7 days.
- Time frame
- 7 days
- Population
Source ClinicalTrials.gov
Trial
- Title
- Norepinephrine vs Phenylephrine During General Anesthesia
- NCT number
- NCT04789330
- Phases
- PHASE4
- Conditions
- Anesthesia, Surgery, Hypotension
- Interventions
- Norepinephrine, Phenylephrine
- Lead sponsor
- University of California, San Francisco
- Results first posted
- 2025-12-18
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04789330?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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