Comparison · NCT04789330-c6f68011
Norepinephrine vs Phenylephrine: Number of Participants With Acute Kidney Injury (AKI)
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Norepinephrine vs Phenylephrine: Number of Participants With Acute Kidney Injury (AKI). Trial comparisons, record NCT04789330-c6f68011. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04789330-c6f68011
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0774 | 0.066 | 0.0906 | wilson | |
| Risk in group 2 | 0.0743 | 0.0631 | 0.0873 | wilson | |
| Risk difference, group 1 minus group 2 | 0.00309 | -0.0142 | 0.0204 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.04 | 0.83 | 1.31 | log | |
| Odds ratio, group 1 over group 2 | 1.05 | 0.817 | 1.34 | log | |
| Number needed to treat, for one more participant with the outcome on Norepinephrine than on Phenylephrine | 323 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Norepinephrine | Norepinephrine continuous infusion as the first line vasopressor~Norepinephrine: Norepinephrine administered during anesthesia | 140 | 1,809 | OG000 |
| Group 2 | Phenylephrine | Phenylephrine continuous infusion as the first line vasopressor~Phenylephrine: Phenylephrine administered during anesthesia | 135 | 1,817 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Acute Kidney Injury (AKI)
- Description
AKI is measured using the Kidney Disease: Improving Global Outcomes (KDIGO) definition based on serum creatinine. Acute kidney injury is defined as an increase in serum creatinine ≥ 0.3 mg/dL within 48 hours, or an increase in serum creatinine ≥ 1.5-fold from baseline within 7 days, or initiation of renal replacement therapy within 7 days.
- Time frame
- 7 days
- Population
Source ClinicalTrials.gov
Trial
- Title
- Norepinephrine vs Phenylephrine During General Anesthesia
- NCT number
- NCT04789330
- Phases
- PHASE4
- Conditions
- Anesthesia, Surgery, Hypotension
- Interventions
- Norepinephrine, Phenylephrine
- Lead sponsor
- University of California, San Francisco
- Results first posted
- 2025-12-18
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04789330?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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