Comparison · NCT04791969-1f657bdf
Naltrexone With Ecological Momentary Intervention vs Placebo With Ecological Momentary Intervention: Adherent to PrEP or to Antiretroviral Medication
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Naltrexone With Ecological Momentary Intervention vs Placebo With Ecological Momentary Intervention: Adherent to PrEP or to Antiretroviral Medication. Trial comparisons, record NCT04791969-1f657bdf. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04791969-1f657bdf
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.714 | 0.5 | 0.862 | wilson | |
| Risk in group 2 | 0.778 | 0.453 | 0.937 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0635 | -0.33 | 0.294 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.918 | 0.59 | 1.43 | log | |
| Odds ratio, group 1 over group 2 | 0.714 | 0.114 | 4.47 | log | |
| Number needed to treat, for one fewer participant with the outcome on Naltrexone With Ecological Momentary Intervention than on Placebo With Ecological Momentary Intervention | 15.8 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Naltrexone With Ecological Momentary Intervention | Naltrexone Hydrochloride, 50 mg., intermittent with ecological momentary assessment (EMA)~Naltrexone Hydrochloride: Intermittent Oral Naltrexone, 50 mg~Ecological Momentary Intervention: Receive ecological momentary intervention if ecological momentary assessment reports meth craving, stress, not taking study drug, or antecedents detected for high risk meth use. | 15 | 21 | OG000 |
| Group 2 | Placebo With Ecological Momentary Intervention | Placebo, intermittent with ecological momentary assessment (EMA)~Placebo: Intermittent Oral Placebo~Ecological Momentary Intervention: Receive ecological momentary intervention if ecological momentary assessment reports meth craving, stress, not taking study drug, or antecedents detected for high risk meth use. | 7 | 9 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- OTHER_PRE_SPECIFIED
- Title
- Adherent to PrEP or to Antiretroviral Medication
- Description
- As measured by PrEP drug levels being detected in HIV negative participants (PrEP Adherent and viral suppression rates in HIV positive participants (Antiretroviral treatment adherent)
- Time frame
- At the end of treatment at the 12-week visit
- Population
- Participants who are HIV-negative and who provided samples for PrEP drug levels testing at final visit, or participants who are living with HIV and provided samples for HIV viral load testing
Source ClinicalTrials.gov
Trial
- Title
- Intermittent Oral Naltrexone Enhanced With an Ecological Momentary Intervention for Methamphetamine-using MSM
- NCT number
- NCT04791969
- Phases
- PHASE2
- Conditions
- Methamphetamine Use Disorder
- Interventions
- Naltrexone Hydrochloride, Placebo, Ecological Momentary Intervention
- Lead sponsor
- Glenn-Milo Santos
- Results first posted
- 2025-10-27
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04791969?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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