Comparison · NCT04844970-be584f82
Anamorelin vs Placebo: Number of Participants With Treatment-related Adverse Events as Assessed by CTCAE v5.0
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Anamorelin vs Placebo: Number of Participants With Treatment-related Adverse Events as Assessed by CTCAE v5.0. Trial comparisons, record NCT04844970-be584f82. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04844970-be584f82
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0 | 0 | 0.658 | wilson | |
| Risk in group 2 | 0.5 | 0.0945 | 0.905 | wilson | |
| Risk difference, group 1 minus group 2 | -0.5 | -0.905 | 0.273 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | log | a group has no participants with the outcome | |||
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat, for one fewer participant with the outcome on Anamorelin than on Placebo | 2 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Anamorelin | Patients randomized to anamorelin HCL will take it daily for 24 weeks starting 3-5 days prior to chemotherapy.~Anamorelin Hydrochloride: Anamorelin HCl is an orally-active selective ghrelin receptor agonist which has shown anabolic and appetite-stimulating effects. | 0 | 2 | OG000 |
| Group 2 | Placebo | Patients randomized to Placebo will take it daily for 24 weeks starting 3-5 days prior to chemotherapy. | 1 | 2 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Treatment-related Adverse Events as Assessed by CTCAE v5.0
- Description
- expected toxicities for Chemotherapies (FOLFIRINOX and Gemcitabine/Nab-Paclitaxel) will be assessed by CTCAE v5.0
- Time frame
- from baseline to week 25 (end of study)
- Population
2 patients on the anamorelin arm both withdrew, data was collected until withdraw of consent. One patient on the placebo arm ended the study prior to week 13 (data collected up until they ended) and another patient's data was analyzed through week 25.
Source ClinicalTrials.gov
Trial
- Title
- Anamorelin Study for Advanced Pancreatic Cancer
- NCT number
- NCT04844970
- Phases
- PHASE2
- Conditions
- Metastatic Pancreatic Cancer
- Interventions
- Anamorelin Hydrochloride, Placebo
- Lead sponsor
- Lahey Clinic
- Results first posted
- 2025-11-17
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04844970?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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