Comparison · NCT04871711-c20877ff
Delgocitinib Cream 20 mg/g vs Cream Vehicle: Number of Participants With Reduction of HESD Itch Score (Weekly Average) of ≥4 Points From Baseline at Week 2
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Delgocitinib Cream 20 mg/g vs Cream Vehicle: Number of Participants With Reduction of HESD Itch Score (Weekly Average) of ≥4 Points From Baseline at Week 2. Trial comparisons, record NCT04871711-c20877ff. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04871711-c20877ff
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.155 | 0.119 | 0.198 | wilson | |
| Risk in group 2 | 0.0621 | 0.0341 | 0.111 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0927 | 0.0327 | 0.144 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 2.49 | 1.3 | 4.78 | log | |
| Odds ratio, group 1 over group 2 | 2.77 | 1.36 | 5.61 | log | |
| Number needed to treat, for one more participant with the outcome on Delgocitinib Cream 20 mg/g than on Cream Vehicle | 10.8 | 6.92 | 30.6 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: vehicle.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Delgocitinib Cream 20 mg/g | Twice-daily topical application for 16 weeks \>~\> Delgocitinib cream: Cream for topical application | 50 | 323 | OG000 |
| Group 2 | Cream Vehicle | Twice-daily topical application for 16 weeks \>~\> Cream vehicle: The cream vehicle is similar to the delgocitinib cream except that it does not contain any active ingredient. | 10 | 161 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Reduction of HESD Itch Score (Weekly Average) of ≥4 Points From Baseline at Week 2
- Description
The Hand Eczema Symptom Diary (HESD) is an eDiary in which participants will assess the worst severity of 6 individual signs and symptoms of CHE over the past 24 hours using an 11-point numeric rating scale with anchors of 0 ='no (symptom)' and 10 ='severe (symptom)' throughout the trial on a daily basis. This endpoint will only assess the 'itch' component and will be evaluated among participants with a baseline HESD itch score (weekly average) ≥4 points.
- Time frame
- 2 weeks
- Population
Source ClinicalTrials.gov
Trial
- Title
- Efficacy and Safety of Delgocitinib Cream in Adults With Moderate to Severe Chronic Hand Eczema
- NCT number
- NCT04871711
- Phases
- PHASE3
- Conditions
- Chronic Hand Eczema
- Interventions
- Delgocitinib cream, Cream vehicle
- Lead sponsor
- LEO Pharma
- Results first posted
- 2024-09-23
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04871711?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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