Comparison · NCT04979442-sae
Milademetan vs Trabectedin: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Milademetan vs Trabectedin: serious adverse events. Trial comparisons, record NCT04979442-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT04979442-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.36 | 0.267 | 0.466 | wilson | |
| Risk in group 2 | 0.481 | 0.374 | 0.589 | wilson | |
| Risk difference, group 1 minus group 2 | -0.121 | -0.264 | 0.0295 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.749 | 0.521 | 1.08 | log | |
| Odds ratio, group 1 over group 2 | 0.608 | 0.326 | 1.13 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Milademetan than on Trabectedin | 8.3 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Milademetan | milademetan 260 mg once daily orally on Days 1 to 3 and Days 15 to 17 of each 28-day cycle | 31 | 86 | EG000 |
| Group 2 | Trabectedin | trabectedin 1.5 mg/m2 body surface area as a 24-hour IV infusion, every 3 weeks | 38 | 79 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- From the first dose date to 30 days after the last dose date or the primary study completion date whichever came first; up to 26.6 months.
Source ClinicalTrials.gov
Trial
- Title
- Treatment of Milademetan Versus Trabectedin in Patient With Dedifferentiated Liposarcoma
- NCT number
- NCT04979442
- Phases
- PHASE3
- Conditions
- Dedifferentiated Liposarcoma
- Interventions
- RAIN-32, Trabectedin
- Lead sponsor
- Rain Oncology Inc
- Results first posted
- 2025-01-14
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT04979442?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
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GET https://conductscience.org/api/comparisons/v1/NCT04979442-sae