Comparison · NCT05081063-bde393f0
Low Titer O+ Whole Blood vs Component Therapy: Mortality
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Low Titer O+ Whole Blood vs Component Therapy: Mortality. Trial comparisons, record NCT05081063-bde393f0. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05081063-bde393f0
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.1 | 0.0396 | 0.231 | wilson | |
| Risk in group 2 | 0.106 | 0.0628 | 0.172 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00569 | -0.0957 | 0.132 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.946 | 0.327 | 2.74 | log | |
| Odds ratio, group 1 over group 2 | 0.94 | 0.288 | 3.07 | log | |
| Number needed to treat, for one fewer participant with the outcome on Low Titer O+ Whole Blood than on Component Therapy | 176 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Low Titer O+ Whole Blood | Low Titer O+ Whole blood provided to Level A trauma patients | 4 | 40 | OG000 |
| Group 2 | Component Therapy | Component Therapy of O+ pRBC and FFP dispatched to trauma bay for level A traumas | 13 | 123 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Mortality
- Description
Assessment of mortality~This is a composite measurement which includes the following in order to be assessed as pulseless with no respiratory drive or brain death:~1. there is no evidence of arousal or awareness to maximal external stimuli~2. pupils are fixed in a midsized or dilated position and non reactive to light~3. corneal, oculocephalic and oculovestibular reflexes are absent~4. There is no facial movement to noxious stimuli~5. the gag reflex is absent to bilateral posterior pharyngeal stimuli~6. the cough reflex is absent to deep tracheal suctioning~7. there is no brain mediated motor response to noxious stimuli of the limbs~8. spontaneous respirations are not observed when apnea test targets reach pH \<7.30 and PaCO2 \>60mmhg
- Time frame
In patients surviving at least 24 hours who were included in analysis of outcome measures, we assessed survival to hospital discharge. This means the duration of time in the hospital up to discharge with a maximum of 30 days.
- Population
Source ClinicalTrials.gov
Trial
- Title
- Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients
- NCT number
- NCT05081063
- Phases
- PHASE3
- Conditions
- Hemorrhagic Shock, Acute Blood Loss Anemia, Traumatic Brain Injury
- Interventions
- Routine labs
- Lead sponsor
- Loma Linda University
- Results first posted
- 2025-08-08
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05081063?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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