Comparison · NCT05094154-deaths
Anti-pseudomonal Cephalosporin vs Anti-pseudomonal Penicillin: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Anti-pseudomonal Cephalosporin vs Anti-pseudomonal Penicillin: deaths from any cause. Trial comparisons, record NCT05094154-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05094154-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0857 | 0.0712 | 0.103 | wilson | |
| Risk in group 2 | 0.0817 | 0.068 | 0.0979 | wilson | |
| Risk difference, group 1 minus group 2 | 0.00394 | -0.0178 | 0.0258 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.05 | 0.809 | 1.36 | log | |
| Odds ratio, group 1 over group 2 | 1.05 | 0.794 | 1.4 | log | |
| Number needed to harm, for one more death from any cause on Anti-pseudomonal Cephalosporin than on Anti-pseudomonal Penicillin | 254 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Anti-pseudomonal Cephalosporin | Participants in the anti-pseudomonal cephalosporin arm will receive at least one dose of an anti-pseudomonal cephalosporin.~anti-pseudomonal cephalosporin: Providers will be prompted to order an anti-pseudomonal cephalosporin, such as cefepime with a dose range of 500 mg, 1,000 mg, or 2,000 mg, and frequency every 6, 8, 12, or 24 hours based on provider discretion. | 104 | 1,214 | EG000 |
| Group 2 | Anti-pseudomonal Penicillin | Participants in the anti-pseudomonal penicillin arm will receive at least one dose of an anti-pseudomonal penicillin.~anti-pseudomonal penicillin: Providers will be prompted to order anti-pseudomonal penicillin, such as piperacillin-tazobactam with a dose range of 3.375 g or 4.5 g and frequency every 6, 8, or 12 hours based on provider discretion. | 106 | 1,297 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- 28 days.
Source ClinicalTrials.gov
Trial
- Title
- Effect of Antibiotic Choice On ReNal Outcomes (ACORN)
- NCT number
- NCT05094154
- Phases
- PHASE4
- Conditions
- Sepsis, AKI, Neurotoxicity
- Interventions
- anti-pseudomonal cephalosporin, anti-pseudomonal penicillin
- Lead sponsor
- Vanderbilt University Medical Center
- Results first posted
- 2023-12-22
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05094154?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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