Comparison · NCT05102162-3da9e481
Continuous Antibiotic Dose Over 24 Hours Arm vs Intermittent Antibiotic Dose Over 30 Minutes: Mortality Between Patients Treated With Continuous and Intermittent Infusion Beta-lactam Regimens
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Continuous Antibiotic Dose Over 24 Hours Arm vs Intermittent Antibiotic Dose Over 30 Minutes: Mortality Between Patients Treated With Continuous and Intermittent Infusion Beta-lactam Regimens. Trial comparisons, record NCT05102162-3da9e481. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05102162-3da9e481
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.4 | 0.118 | 0.769 | wilson | |
| Risk in group 2 | 0.154 | 0.0433 | 0.422 | wilson | |
| Risk difference, group 1 minus group 2 | 0.246 | -0.144 | 0.632 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 2.6 | 0.491 | 13.8 | log | |
| Odds ratio, group 1 over group 2 | 3.67 | 0.354 | 38 | log | |
| Number needed to treat, for one more participant with the outcome on Continuous Antibiotic Dose Over 24 Hours Arm than on Intermittent Antibiotic Dose Over 30 Minutes | 4.06 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Continuous Antibiotic Dose Over 24 Hours Arm | Subjects will be receiving a continuous dose of antibiotic prescribed by their doctor for the duration they choose.~Cefepime, Meropenem, or Piperacillin/Tazobactam: A 1:1 randomization scheme based on the infusion duration (continuous over 24 hours or intermittent over 30 minutes) with stratification based on the beta-lactam prescribed (cefepime, meropenem, or piperacillin/tazobactam) | 2 | 5 | OG000 |
| Group 2 | Intermittent Antibiotic Dose Over 30 Minutes | Subjects will be receiving an intermittent dose of antibiotic prescribed by their doctor for the duration they choose.~Cefepime, Meropenem, or Piperacillin/Tazobactam: A 1:1 randomization scheme based on the infusion duration (continuous over 24 hours or intermittent over 30 minutes) with stratification based on the beta-lactam prescribed (cefepime, meropenem, or piperacillin/tazobactam) | 2 | 13 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Mortality Between Patients Treated With Continuous and Intermittent Infusion Beta-lactam Regimens
- Description
- Time frame
- 4 weeks
- Population
Source ClinicalTrials.gov
Trial
- Title
- BL Infusion Trial:Beta-lactam Continuous Versus Intermittent Infusion and Associated Bacterial Resistance and Therapy Outcomes in Critically Ill Patients With Severe Pneumonia
- NCT number
- NCT05102162
- Phases
- PHASE4
- Conditions
- Pneumonia
- Interventions
- Cefepime, Meropenem, or Piperacillin/Tazobactam, Cefepime, Meropenem, or Piperacillin/Tazobactam
- Lead sponsor
- University of Florida
- Results first posted
- 2023-12-12
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05102162?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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