Comparison · NCT05174416-4b6136d7
Mavacamten vs Placebo: Proportion of Participants Achieving a Valsalva LVOT Peak Gradient < 50 mmHg at Week 30.
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Mavacamten vs Placebo: Proportion of Participants Achieving a Valsalva LVOT Peak Gradient < 50 mmHg at Week 30. Trial comparisons, record NCT05174416-4b6136d7. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05174416-4b6136d7
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.593 | 0.46 | 0.713 | wilson | |
| Risk in group 2 | 0.0741 | 0.0206 | 0.234 | wilson | |
| Risk difference, group 1 minus group 2 | 0.519 | 0.311 | 0.65 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 8 | 2.07 | 30.9 | log | |
| Odds ratio, group 1 over group 2 | 18.2 | 3.9 | 84.7 | log | |
| Number needed to treat, for one more participant with the outcome on Mavacamten than on Placebo | 1.93 | 1.54 | 3.22 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Mavacamten | Mavacamten Capsules~Mavacamten: Mavacamten Capsules | 32 | 54 | OG000 |
| Group 2 | Placebo | Matching Placebo Capsules~Placebo: Matching PBO capsules during placebo controlled period，and mavacamten capsules during long term extension period | 2 | 27 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Proportion of Participants Achieving a Valsalva LVOT Peak Gradient < 50 mmHg at Week 30.
- Description
- To compare the effect of a 30-week course of mavacamten with placebo on LVOT obstruction.
- Time frame
- 30 weeks
- Population
Source ClinicalTrials.gov
Trial
- Title
- A Study to Evaluate the Efficacy and Safety of Mavacamten in Chinese Adults With Symptomatic Obstructive HCM
- NCT number
- NCT05174416
- Phases
- PHASE3
- Conditions
- Obstructive Hypertrophic Cardiomyopathy
- Interventions
- Mavacamten, Placebo
- Lead sponsor
- LianBio LLC
- Results first posted
- 2024-09-19
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05174416?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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