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Comparison · NCT05176353-deaths

Pre-VAP Diagnostic Stewardship vs VAP Diagnostic Stewardship: deaths from any cause

Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.

2 sourcestrial-comparisons-2026-03-23-0.1.0

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ConductScience Library. Pre-VAP Diagnostic Stewardship vs VAP Diagnostic Stewardship: deaths from any cause. Trial comparisons, record NCT05176353-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05176353-deaths

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Measures6

Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.

MeasureValue95% interval, lower95% interval, upperMethodNote
Risk in group 10.3960.3820.411wilson
Risk in group 20.4130.3770.451wilson
Risk difference, group 1 minus group 2-0.0172-0.05720.022newcombe hybrid score
Risk ratio, group 1 over group 20.9580.871.06log
Odds ratio, group 1 over group 20.9310.791.1log
Number needed to treat, for one fewer death from any cause on Pre-VAP Diagnostic Stewardship than on VAP Diagnostic Stewardship58.2from the risk difference intervalthe interval includes no difference

Groups2

Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.

GroupTitleDescriptionWith the outcomeAnalysedClinicalTrials.gov code
Group 1Pre-VAP Diagnostic StewardshipPre-intervention historical control group - all patients hospitalized in study ICUs who were mechanically ventilated Feb 17, 2017- Feb 16, 2022.1,6664,205EG000
Group 2VAP Diagnostic Stewardship
Intervention group - all patients hospitalized in study ICUs who were mechanically ventilated Feb 17, 2022 - Feb 17, 2023.~VAP diagnostic stewardship bundle: Multifaceted VAP diagnostic stewardship bundle targeting the respiratory culture testing workflow through a custom order set within the institutional electronic medical record. Interventions will be made at the three levels of the diagnostic testing pathway (ordering, collection and reporting of test results). Full details available in detailed study description.
284687EG001

Harm

What it counts
Total, all-cause mortality
Time frame
Up to 6 years (including 5 years pre-intervention and 1-year post intervention).

Source ClinicalTrials.gov

Trial

Title
Ventilator-associated Pneumonia (VAP) Diagnostic Stewardship Trial
NCT number
NCT05176353
Phases
NA
Conditions
VAP - Ventilator Associated Pneumonia
Interventions
VAP diagnostic stewardship bundle
Lead sponsor
University of Michigan
Results first posted
2024-12-03

Source ClinicalTrials.gov

Source

Release
trial-comparisons-2026-03-23-0.1.0
Release manifest SHA-256
f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
AACT copy
2026-03-23
Tables read
outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet

Source ClinicalTrials.gov

Sources 2

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.

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