Comparison · NCT05219968-b2016c71
LYR-210 vs Sham Procedure Control: Participants With Rescue Treatments for CRS Through Week 24
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. LYR-210 vs Sham Procedure Control: Participants With Rescue Treatments for CRS Through Week 24. Trial comparisons, record NCT05219968-b2016c71. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05219968-b2016c71
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0968 | 0.0562 | 0.162 | wilson | |
| Risk in group 2 | 0.106 | 0.0523 | 0.203 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00929 | -0.114 | 0.0749 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.912 | 0.377 | 2.21 | log | |
| Odds ratio, group 1 over group 2 | 0.903 | 0.338 | 2.42 | log | |
| Number needed to treat, for one fewer participant with the outcome on LYR-210 than on Sham Procedure Control | 108 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: sham.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | LYR-210 | Single administration of LYR-210 drug matrix (7500 μg)~LYR-210: LYR-210 drug matrix (mometasone furoate)~Background Therapy: Daily Saline Irrigation | 12 | 124 | OG000 |
| Group 2 | Sham Procedure Control | Single mock administration procedure~Sham procedure control: Sham procedure control~Background Therapy: Daily Saline Irrigation | 7 | 66 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Participants With Rescue Treatments for CRS Through Week 24
- Description
This endpoint is descriptively summarized per the prespecified plan. This includes participants that used systemic corticosteroid for any reason as well as participants that were recommended/underwent sinonasal surgery.
- Time frame
- Week 24
- Population
- ITT Analysis Set
Source ClinicalTrials.gov
Trial
- Title
- Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults
- NCT number
- NCT05219968
- Phases
- PHASE3
- Conditions
- Chronic Sinusitis, Chronic Rhinosinusitis (Diagnosis)
- Interventions
- LYR-210, Sham procedure control, Background Therapy
- Lead sponsor
- Lyra Therapeutics
- Results first posted
- 2025-05-02
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05219968?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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