Comparison · NCT05259722-sae
Delgocitinib Cream 20 mg/g vs Alitretinoin Capsules 30 mg Per Capsule: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Delgocitinib Cream 20 mg/g vs Alitretinoin Capsules 30 mg Per Capsule: serious adverse events. Trial comparisons, record NCT05259722-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05259722-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0198 | 0.00847 | 0.0454 | wilson | |
| Risk in group 2 | 0.0486 | 0.028 | 0.083 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0288 | -0.065 | 0.00407 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.407 | 0.145 | 1.14 | log | |
| Odds ratio, group 1 over group 2 | 0.395 | 0.137 | 1.14 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Delgocitinib Cream 20 mg/g than on Alitretinoin Capsules 30 mg Per Capsule | 34.7 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Delgocitinib Cream 20 mg/g | Delgocitinib Cream 20 mg/g (N=253) | 5 | 253 | EG000 |
| Group 2 | Alitretinoin Capsules 30 mg Per Capsule | Alitretinoin Capsules 30 mg Per Capsule (N=247) | 12 | 247 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- From baseline to Week 26
Source ClinicalTrials.gov
Trial
- Title
- A 24 Week Trial to Compare the Efficacy and Safety of Delgocitinib Cream 20 mg/g Twice-daily With Alitretinoin Capsules Once-daily in Adult Participants With Severe Chronic Hand Eczema
- NCT number
- NCT05259722
- Phases
- PHASE3
- Conditions
- Chronic Hand Eczema
- Interventions
- Delgocitinib, Toctino
- Lead sponsor
- LEO Pharma
- Results first posted
- 2025-03-14
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05259722?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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