Comparison · NCT05267652-b8b95f44
Preoxygenation With Non-Invasive Positive Pressure Ventilation Group vs Preoxygenation With Facemask Oxygen Group: 28-day In-hospital Mortality
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Preoxygenation With Non-Invasive Positive Pressure Ventilation Group vs Preoxygenation With Facemask Oxygen Group: 28-day In-hospital Mortality. Trial comparisons, record NCT05267652-b8b95f44. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05267652-b8b95f44
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.324 | 0.289 | 0.361 | wilson | |
| Risk in group 2 | 0.331 | 0.296 | 0.368 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00676 | -0.0576 | 0.0442 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.98 | 0.838 | 1.14 | log | |
| Odds ratio, group 1 over group 2 | 0.97 | 0.769 | 1.22 | log | |
| Number needed to treat, for one fewer participant with the outcome on Preoxygenation With Non-Invasive Positive Pressure Ventilation Group than on Preoxygenation With Facemask Oxygen Group | 148 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Preoxygenation With Non-Invasive Positive Pressure Ventilation Group | Patients assigned to preoxygenation with non-invasive positive pressure ventilation will receive non-invasive mechanical ventilation via a tight-fitting mask from the initiation of preoxygenation until the initiation of laryngoscopy. Trial protocol will not dictate the brand or type of mechanical ventilator that will be used to deliver non-invasive ventilation.~Preoxygenation with Non-Invasive Positive Pressure Ventilation: The delivery of oxygen and ventilation by non-invasive mechanical ventilation via a tight-fitting mask from the initiation of preoxygenation until the initiation of laryngoscopy. Trial protocol will not dictate the brand or type of mechanical ventilator that will be used to deliver non-invasive ventilation. | 209 | 645 | OG000 |
| Group 2 | Preoxygenation With Facemask Oxygen Group | For patients randomized to preoxygenation with facemask oxygen, supplemental oxygen will be administered via a non-rebreather mask or bag-mask device without manual ventilation from the initiation of preoxygenation until induction. Trial protocol will not dictate the brand or type of facemask. The decision between use of a non-rebreather mask and use of a bag-mask device will be made by treating clinicians. The decision of whether to provide manual ventilation with a bag-mask device between induction and laryngoscopy will be made by treating clinicians.~Facemask Oxygen: The delivery of supplemental oxygen via a non-rebreather mask or bag-mask device without manual ventilation from the initiation of preoxygenation until induction. Trial protocol will not dictate the brand or type of facemask. The decision between use of a non-rebreather mask and use of a bag-mask device will be made by treating clinicians. The decision of whether to provide manual ventilation with a bag-mask device between induction and laryngoscopy will be made by treating clinicians. | 217 | 656 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- OTHER_PRE_SPECIFIED
- Title
- 28-day In-hospital Mortality
- Description
- Time frame
- 28 days
- Population
Source ClinicalTrials.gov
Trial
- Title
- Pragmatic Trial Examining Oxygenation Prior to Intubation
- NCT number
- NCT05267652
- Phases
- NA
- Conditions
- Acute Respiratory Failure
- Interventions
- Preoxygenation with Non-Invasive Positive Pressure Ventilation, Facemask Oxygen
- Lead sponsor
- Vanderbilt University Medical Center
- Results first posted
- 2024-12-09
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05267652?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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