Comparison · NCT05296629-68cb47cb
DFD-29 vs Placebo: Investigator's Global Assessment (IGA) Treatment Success Compared to Placebo.
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. DFD-29 vs Placebo: Investigator's Global Assessment (IGA) Treatment Success Compared to Placebo. Trial comparisons, record NCT05296629-68cb47cb. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05296629-68cb47cb
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.648 | 0.559 | 0.727 | wilson | |
| Risk in group 2 | 0.313 | 0.222 | 0.421 | wilson | |
| Risk difference, group 1 minus group 2 | 0.335 | 0.196 | 0.456 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 2.07 | 1.46 | 2.94 | log | |
| Odds ratio, group 1 over group 2 | 4.04 | 2.22 | 7.37 | log | |
| Number needed to treat, for one more participant with the outcome on DFD-29 than on Placebo | 2.98 | 2.19 | 5.11 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | DFD-29 | DFD-29 (40 mg) extended release capsules~DFD-29: DFD-29 (40 mg) extended release capsules | 79 | 122 | OG000 |
| Group 2 | Placebo | Placebo capsules matching DFD-29~Placebo: Placebo capsules | 25 | 80 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Investigator's Global Assessment (IGA) Treatment Success Compared to Placebo.
- Description
Proportion of subjects with IGA (modified scale without erythema) 'treatment success' - Grade 0 or 1 at Week 16 with at least 2 grade reduction from Baseline to Week 16, in the DFD-29 group compared to Placebo.~The modified IGA scale is a 5-point scale from Grade 0 to Grade 4, wherein Grade 0 is Clear, Grade 1 is Near Clear, Grade 2 is Mild, Grade 3 is Moderate and Grade 4 is Severe Rosacea. A lowering of the score with treatment indicates an improvement in the disease condition and a beneficial outcome.
- Time frame
- Baseline to Week 16.
- Population
- ITT population defined as, 'All randomized subjects'
Source ClinicalTrials.gov
Trial
- Title
- A Randomized, Double-Blind Study to Assess the Safety, Efficacy and Tolerability of Oral DFD-29 Capsules for the Treatment of Rosacea.
- NCT number
- NCT05296629
- Phases
- PHASE3
- Conditions
- Papulopustular Rosacea
- Interventions
- DFD-29, Doxycycline, Placebo
- Lead sponsor
- Journey Medical Corporation
- Results first posted
- 2024-12-03
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05296629?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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