Comparison · NCT05327296-1a0da123
Isoflurane vs Propofol: Other Secondary: The Effect of Isoflurane vs Propofol on Mortality at 3 Months After Randomization
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Isoflurane vs Propofol: Other Secondary: The Effect of Isoflurane vs Propofol on Mortality at 3 Months After Randomization. Trial comparisons, record NCT05327296-1a0da123. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05327296-1a0da123
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.301 | 0.237 | 0.373 | wilson | |
| Risk in group 2 | 0.31 | 0.223 | 0.414 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00977 | -0.131 | 0.104 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.969 | 0.658 | 1.43 | log | |
| Odds ratio, group 1 over group 2 | 0.955 | 0.546 | 1.67 | log | |
| Number needed to treat, for one fewer participant with the outcome on Isoflurane than on Propofol | 102 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Isoflurane | Inhaled isoflurane administered via Sedaconda ACD-S~Isoflurane: Inhaled isoflurane administered by Sedaconda ACD-S | 52 | 173 | OG000 |
| Group 2 | Propofol | Propofol administered as intravenous infusion~Propofol: Intravenous infusion of propofol | 27 | 87 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Other Secondary: The Effect of Isoflurane vs Propofol on Mortality at 3 Months After Randomization
- Description
- Participants reported represent participants that died between randomization and 3 months in the Safety population
- Time frame
- At 3 months after randomization
- Population
Source ClinicalTrials.gov
Trial
- Title
- Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2)
- NCT number
- NCT05327296
- Phases
- PHASE3
- Conditions
- Sedation
- Interventions
- Isoflurane, Propofol
- Lead sponsor
- Sedana Medical
- Results first posted
- 2026-03-03
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05327296?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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