Comparison · NCT05327296-a66238e4
Isoflurane (Run-ins and Randomized) vs Propofol: Other Secondary: The Use of Restraints in Patients Receiving Isoflurane vs Propofol
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Isoflurane (Run-ins and Randomized) vs Propofol: Other Secondary: The Use of Restraints in Patients Receiving Isoflurane vs Propofol. Trial comparisons, record NCT05327296-a66238e4. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05327296-a66238e4
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.798 | 0.732 | 0.851 | wilson | |
| Risk in group 2 | 0.839 | 0.748 | 0.902 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0414 | -0.132 | 0.0642 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.951 | 0.844 | 1.07 | log | |
| Odds ratio, group 1 over group 2 | 0.756 | 0.382 | 1.49 | log | |
| Number needed to treat, for one fewer participant with the outcome on Isoflurane (Run-ins and Randomized) than on Propofol | 24.2 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Isoflurane (Run-ins and Randomized) | Inhaled isoflurane administered via Sedaconda ACD-S~3-5 run-in patients treated with isoflurane were enrolled at each site prior to randomization | 138 | 173 | OG000 |
| Group 2 | Propofol | Propofol administered as intravenous infusion~Propofol: Intravenous infusion of propofol | 73 | 87 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Other Secondary: The Use of Restraints in Patients Receiving Isoflurane vs Propofol
- Description
- Incidence of restraints measured twice daily
- Time frame
- From start to end of study treatment (up to 48 (±6) hours)
- Population
- This Outcome Measure was pre-specified to be assess based on the Safety Population (run-in patients and Randomized participants that received any study drug)
Source ClinicalTrials.gov
Trial
- Title
- Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2)
- NCT number
- NCT05327296
- Phases
- PHASE3
- Conditions
- Sedation
- Interventions
- Isoflurane, Propofol
- Lead sponsor
- Sedana Medical
- Results first posted
- 2026-03-03
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05327296?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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