Comparison · NCT05352815-sae
Icodec vs IcoSema: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Icodec vs IcoSema: serious adverse events. Trial comparisons, record NCT05352815-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05352815-sae
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.107 | 0.0855 | 0.133 | wilson | |
| Risk in group 2 | 0.0916 | 0.0717 | 0.116 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0155 | -0.0173 | 0.0485 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.17 | 0.841 | 1.63 | log | |
| Odds ratio, group 1 over group 2 | 1.19 | 0.825 | 1.72 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Icodec than on IcoSema | 64.4 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Icodec | Participants received once-weekly subcutaneous injections of 700 U/mL of insulin icodec for 52 weeks. | 69 | 644 | EG000 |
| Group 2 | IcoSema | Participants received once-weekly subcutaneous injections of 700 units per milliliter (U/mL) of insulin icodec and 2 milligrams per milliliter (mg/mL) of semaglutide for 52 weeks. | 59 | 644 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Week 0 to week 57
Source ClinicalTrials.gov
Trial
- Title
A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Weekly Insulin Icodec
- NCT number
- NCT05352815
- Phases
- PHASE3
- Conditions
- Diabetes Mellitus, Type 2
- Interventions
- IcoSema, Insulin icodec
- Lead sponsor
- Novo Nordisk A/S
- Results first posted
- 2025-04-03
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05352815?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT05352815-sae