Comparison · NCT05401149-deaths
IV Rt-PA Cohort vs Non-reperfusion Cohort: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. IV Rt-PA Cohort vs Non-reperfusion Cohort: deaths from any cause. Trial comparisons, record NCT05401149-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05401149-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.395 | 0.361 | 0.43 | wilson | |
| Risk in group 2 | 0.388 | 0.355 | 0.423 | wilson | |
| Risk difference, group 1 minus group 2 | 0.00641 | -0.0419 | 0.0547 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.02 | 0.898 | 1.15 | log | |
| Odds ratio, group 1 over group 2 | 1.03 | 0.838 | 1.26 | log | |
| Number needed to harm, for one more death from any cause on IV Rt-PA Cohort than on Non-reperfusion Cohort | 156 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | IV Rt-PA Cohort | Acute Ischaemic Stroke (AIS) patients aged \> 80 years who received intravenous (IV) Recombinant Tissue Plasminogen Activator (rt-PA) (Alteplase) within 4.5 hours of symptom onset | 308 | 780 | EG000 |
| Group 2 | Non-reperfusion Cohort | Acute Ischaemic Stroke (AIS) patients aged \> 80 years who arrived or were admitted to the hospital within 4.5 hours of symptom onset and did not receive any reperfusion treatments | 303 | 780 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
Source ClinicalTrials.gov
Trial
- Title
- Alteplase Treatment in Elderly Acute Ischaemic Stroke (AIS) Patients
- NCT number
- NCT05401149
- Phases
- Conditions
- Stroke
- Interventions
- rt-PA
- Lead sponsor
- Boehringer Ingelheim
- Results first posted
- 2024-10-17
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05401149?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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