Comparison · NCT05425745-sae
Obicetrapib 10 mg vs Placebo: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Obicetrapib 10 mg vs Placebo: serious adverse events. Trial comparisons, record NCT05425745-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05425745-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0556 | 0.0328 | 0.0927 | wilson | |
| Risk in group 2 | 0.0678 | 0.0348 | 0.128 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0122 | -0.0767 | 0.0375 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.819 | 0.349 | 1.92 | log | |
| Odds ratio, group 1 over group 2 | 0.809 | 0.326 | 2.01 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Obicetrapib 10 mg than on Placebo | 81.7 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Obicetrapib 10 mg | one 10 mg Obicetrapib tablet once daily~Obicetrapib: 10 mg Obicetrapib tablet | 13 | 234 | EG001 |
| Group 2 | Placebo | one placebo tablet once daily~Placebo: placebo tablet made to resemble active | 8 | 118 | EG000 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- From first dose of study drug up to Week 54
Source ClinicalTrials.gov
Trial
- Title
- Evaluate the Effect of Obicetrapib in Patients With HeFH on Top of Maximum Tolerated Lipid-Modifying Therapies.
- NCT number
- NCT05425745
- Phases
- PHASE3
- Conditions
Dyslipidemias, High Cholesterol, Hypercholesterolemia, Familial Hypercholesterolemia, Lipid Metabolism Disorder, Metabolic Disease, Lipid Metabolism, Inborn Errors, Genetic Disease, Inborn, Hyperlipoproteinemias
- Interventions
- Obicetrapib, Placebo
- Lead sponsor
- NewAmsterdam Pharma
- Results first posted
- 2025-06-11
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05425745?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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