Comparison · NCT05478174-cd78a04f
HSK3486 vs Propofol: Percentage of Subjects With Any Injection-site Pain on Numeric Rating Scale ≥1
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. HSK3486 vs Propofol: Percentage of Subjects With Any Injection-site Pain on Numeric Rating Scale ≥1. Trial comparisons, record NCT05478174-cd78a04f. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05478174-cd78a04f
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.165 | 0.124 | 0.215 | wilson | |
| Risk in group 2 | 0.453 | 0.37 | 0.539 | wilson | |
| Risk difference, group 1 minus group 2 | -0.288 | -0.384 | -0.191 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.363 | 0.26 | 0.508 | log | |
| Odds ratio, group 1 over group 2 | 0.238 | 0.147 | 0.385 | log | |
| Number needed to treat, for one fewer participant with the outcome on HSK3486 than on Propofol | 3.47 | 2.61 | 5.24 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | HSK3486 | HSK3486 for general anesthesia induction~HSK3486: HSK3486 for induction of general anesthesia | 42 | 255 | OG000 |
| Group 2 | Propofol | Propofol for general anesthesia induction~Propofol: Propofol for induction of general anesthesia. | 58 | 128 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Percentage of Subjects With Any Injection-site Pain on Numeric Rating Scale ≥1
- Description
- 0 = No Pain 1-3 = Mild Pain 4-6 = Moderate Pain 7-9 = Severe Pain 10 = Worst pain imaginable
- Time frame
- From start of drug administration to MOAA/S ≤1 (up to 3 minutes)
- Population
Source ClinicalTrials.gov
Trial
- Title
- Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia
- NCT number
- NCT05478174
- Phases
- PHASE3
- Conditions
- General Anesthesia
- Interventions
- HSK3486, Propofol
- Lead sponsor
- Haisco-USA Pharmaceuticals, Inc.
- Results first posted
- 2024-10-29
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05478174?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT05478174-cd78a04f