Comparison · NCT05481216-fad61ee8
PLWHIV With COVID-19 Cases vs PLWHIV Without COVID-19 Controls: Chronic Obstructive Pulmonary Disease
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. PLWHIV With COVID-19 Cases vs PLWHIV Without COVID-19 Controls: Chronic Obstructive Pulmonary Disease. Trial comparisons, record NCT05481216-fad61ee8. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05481216-fad61ee8
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.072 | 0.0525 | 0.0981 | wilson | |
| Risk in group 2 | 0.0433 | 0.0323 | 0.0579 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0287 | 0.0043 | 0.057 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.66 | 1.08 | 2.55 | log | |
| Odds ratio, group 1 over group 2 | 1.71 | 1.08 | 2.7 | log | |
| Number needed to treat, for one more participant with the outcome on PLWHIV With COVID-19 Cases than on PLWHIV Without COVID-19 Controls | 34.9 | 17.6 | 233 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | PLWHIV With COVID-19 Cases | Patients who are at least 18 years of age with documented HIV-1 infection and confirmed SARS-CoV-2 infection by documented, or patient-reported, positive result on PCR testing of a nasopharyngeal or respiratory sample, before 1st April 2021.~COVID-19: Diagnosed with COVID-19 infection~HIV-1 infection: Diagnosed with HIV-1 infection | 36 | 500 | OG000 |
| Group 2 | PLWHIV Without COVID-19 Controls | Patients at least 18 years of age with documented HIV-1 infection.~HIV-1 infection: Diagnosed with HIV-1 infection | 43 | 992 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Chronic Obstructive Pulmonary Disease
- Description
- Identification of risk factors for COVID-19 infection within the group of PLHIV: Chronic Obstructive Pulmonary Disease
- Time frame
- Baseline(Last CD4 cell count and HIV-RNA before COVID-19 diagnosis, or most recent for PLHIV without COVID-19)
- Population
The analysis population will consist of PLHIV and COVID-19 with matched PLHIV without COVID-19. 1:2 matching for similar risk of acquiring COVID-19 will be performed according to the following criteria: Age (+/- 5 years); Sex; Ethnicity (where available). Because some of the variables studied will have missing values, multiple imputation using Chained Equations approach (MICE) will be used to fill in missing data. Ten imputations (M=10) will be chosen.
Source ClinicalTrials.gov
Trial
- Title
- HIV-1 & Coronavirus-Coinfection in Europe: Morbidity & Risk Factors of COVID-19 in People Living With HIV
- NCT number
- NCT05481216
- Phases
- Conditions
- HIV-1-infection, COVID-19
- Interventions
- COVID-19, HIV-1 infection
- Lead sponsor
- NEAT ID Foundation
- Results first posted
- 2025-03-24
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05481216?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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