Comparison · NCT05576662-sae
Nirmatrelvir Plus Ritonavir vs Placebo Plus Ritonavir: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Nirmatrelvir Plus Ritonavir vs Placebo Plus Ritonavir: serious adverse events. Trial comparisons, record NCT05576662-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05576662-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0294 | 0.0101 | 0.0829 | wilson | |
| Risk in group 2 | 0.0189 | 0.00334 | 0.0994 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0105 | -0.0723 | 0.0663 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.56 | 0.166 | 14.6 | log | |
| Odds ratio, group 1 over group 2 | 1.58 | 0.16 | 15.5 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Nirmatrelvir Plus Ritonavir than on Placebo Plus Ritonavir | 94.8 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Nirmatrelvir Plus Ritonavir | Participants receive nirmatrelvir (two 150 mg tablets) plus ritonavir (one 100 mg capsule) every 12 hours for 15 days, and attend follow-up visits through week 15. | 3 | 102 | EG000 |
| Group 2 | Placebo Plus Ritonavir | Participants receive placebo to match nirmatrelvir plus ritonavir (one 100 mg capsule) every 12 hours for 15 days, and attend follow-up visits through week 15. | 1 | 53 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- 15 weeks
Source ClinicalTrials.gov
Trial
- Title
- Paxlovid for Treatment of Long Covid
- NCT number
- NCT05576662
- Phases
- PHASE2
- Conditions
- Post-acute Sequelae of SARS-CoV-2 Infection, Long COVID
- Interventions
- Nirmatrelvir, Placebo, Ritonavir
- Lead sponsor
- Stanford University
- Results first posted
- 2024-09-25
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05576662?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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