Comparison · NCT05732454-f61ecb9a
OLE Period: Etrasimod 2 mg (Etrasimod 2 mg in DB Period) vs OLE Period: Etrasimod 2 mg (Placebo in DB Period): Part 1, OLE Period: Number of Participants With Laboratory Test Abnormalities
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. OLE Period: Etrasimod 2 mg (Etrasimod 2 mg in DB Period) vs OLE Period: Etrasimod 2 mg (Placebo in DB Period): Part 1, OLE Period: Number of Participants With Laboratory Test Abnormalities. Trial comparisons, record NCT05732454-f61ecb9a. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05732454-f61ecb9a
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.714 | 0.529 | 0.847 | wilson | |
| Risk in group 2 | 0.72 | 0.524 | 0.857 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00571 | -0.236 | 0.231 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.992 | 0.707 | 1.39 | log | |
| Odds ratio, group 1 over group 2 | 0.972 | 0.294 | 3.22 | log | |
| Number needed to treat, for one fewer participant with the outcome on OLE Period: Etrasimod 2 mg (Etrasimod 2 mg in DB Period) than on OLE Period: Etrasimod 2 mg (Placebo in DB Period) | 175 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | OLE Period: Etrasimod 2 mg (Etrasimod 2 mg in DB Period) | Participants who received etrasimod 2 mg in DB period and then continued to receive etrasimod 2 mg orally once daily in OLE period for maximum of another 52 weeks. | 20 | 28 | OG000 |
| Group 2 | OLE Period: Etrasimod 2 mg (Placebo in DB Period) | Participants who received placebo matched to etrasimod in DB period and then received etrasimod 2 mg orally once daily in OLE period for maximum of another 52 weeks. | 18 | 25 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Part 1, OLE Period: Number of Participants With Laboratory Test Abnormalities
- Description
- Laboratory assessments included hematology, clinical chemistry, urinalysis, other parameters and reflex tests. Number of participants with abnormalities in any of laboratory parameters is reported.
- Time frame
- OLE Period: First dose of study drug in OLE period up to 4 weeks after last dose in OLE period (up to maximum of 56 Weeks)
- Population
Safety analysis set included all participants who received at least 1 dose of study intervention (i.e., Etrasimod or placebo). Participants were analyzed in the treatment groups as they were randomized. Here, Number of Participants Analyzed signifies participants evaluable for this outcome measure.
Source ClinicalTrials.gov
Trial
- Title
- A Study to Learn About the Study Medicine Etrasimod in Adults With Moderate to Severe Atopic Dermatitis (AD) Who Have Already Tried Treatments Taken by Mouth or by Injection
- NCT number
- NCT05732454
- Phases
- PHASE2, PHASE3
- Conditions
- Atopic Dermatitis, Atopic Dermatitis, Unspecified, Eczema, Eczema, Atopic
- Interventions
- etrasimod, Placebo
- Lead sponsor
- Pfizer
- Results first posted
- 2025-05-08
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05732454?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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