Comparison · NCT05952869-fe00c024
Enlicitide Decanoate vs Placebo: Number of Participants Who Discontinued Study Drug Due to an AE
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Enlicitide Decanoate vs Placebo: Number of Participants Who Discontinued Study Drug Due to an AE. Trial comparisons, record NCT05952869-fe00c024. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05952869-fe00c024
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0198 | 0.00773 | 0.0498 | wilson | |
| Risk in group 2 | 0.0297 | 0.0102 | 0.0837 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0099 | -0.0652 | 0.0259 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.667 | 0.152 | 2.92 | log | |
| Odds ratio, group 1 over group 2 | 0.66 | 0.145 | 3.01 | log | |
| Number needed to treat, for one fewer participant with the outcome on Enlicitide Decanoate than on Placebo | 101 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Enlicitide Decanoate | Participants received 20 mg of enlicitide decanoate orally once daily (QD) for up to 52 weeks. | 4 | 202 | OG000 |
| Group 2 | Placebo | Participants received enlicitide decanoate-matching placebo orally QD for up to 52 weeks. | 3 | 101 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Participants Who Discontinued Study Drug Due to an AE
- Description
An AE was defined as any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.
- Time frame
- Up to 56 weeks
- Population
- All participants who received at least 1 dose of study treatment. One participant received enlicitide decanoate at 56 weeks outside of protocol-specified duration of treatment.
Source ClinicalTrials.gov
Trial
- Title
- A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Heterozygous Familial Hypercholesterolemia (MK-0616-017/CORALreef HeFH)
- NCT number
- NCT05952869
- Phases
- PHASE3
- Conditions
- Hypercholesterolemia, Familial Hypercholesterolemia
- Interventions
- Enlicitide Decanoate, Placebo
- Lead sponsor
- Merck Sharp & Dohme LLC
- Results first posted
- 2026-02-24
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05952869?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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