Comparison · NCT05966129-a43d33d6
Acute Pain - Immediate PGx Testing (Modified Intent-to-treat, mITT) vs Acute Pain - Delayed PGx Testing (Modified Intent-to-treat, mITT): Number of Participants With Opioid Persistence
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Acute Pain - Immediate PGx Testing (Modified Intent-to-treat, mITT) vs Acute Pain - Delayed PGx Testing (Modified Intent-to-treat, mITT): Number of Participants With Opioid Persistence. Trial comparisons, record NCT05966129-a43d33d6. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05966129-a43d33d6
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.157 | 0.108 | 0.223 | wilson | |
| Risk in group 2 | 0.144 | 0.096 | 0.21 | wilson | |
| Risk difference, group 1 minus group 2 | 0.013 | -0.0693 | 0.0945 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.09 | 0.636 | 1.87 | log | |
| Odds ratio, group 1 over group 2 | 1.11 | 0.587 | 2.09 | log | |
Number needed to treat, for one more participant with the outcome on Acute Pain - Immediate PGx Testing (Modified Intent-to-treat, mITT) than on Acute Pain - Delayed PGx Testing (Modified Intent-to-treat, mITT) | 76.8 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Acute Pain - Immediate PGx Testing (Modified Intent-to-treat, mITT) | Immediate genetic testing of CYP2D6 and clinical decisions support for pain management prescribing to the healthcare provider~Pharmacogenetic testing: Genetic testing of CYP2D6 and CYP2C19~Clinical decisions support: Prescribing recommendations to the provider based on the pharmacogenetic testing results | 24 | 153 | OG000 |
| Group 2 | Acute Pain - Delayed PGx Testing (Modified Intent-to-treat, mITT) | Delayed genetic testing of CYP2D6 and return of results after the conclusion of the 6-month follow-up period~Pharmacogenetic testing: Genetic testing of CYP2D6 and CYP2C19 | 21 | 146 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Opioid Persistence
- Description
- Opioid persistence defined as a filled prescription for an opioid medication 3-6 months post-surgery in participants who have a genotypic or pheno-converted CYP2D6 activity score ≤ 0.75.
- Time frame
- 3-6 months post-surgery, assessed at 6 months
- Population
- Modified intent to treat (mITT) population, consisting of participants who completed their surgery and have a genotypic or phenoconverted CYP2D6 activity score ≤ 0.75.
Source ClinicalTrials.gov
Trial
- Title
- A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Acute Pain Trial)
- NCT number
- NCT05966129
- Phases
- NA
- Conditions
- Acute Pain
- Interventions
- Pharmacogenetic testing, Clinical decisions support
- Lead sponsor
- Duke University
- Results first posted
- 2025-06-05
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05966129?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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