Comparison · NCT05966129-deaths
Acute Pain - Immediate PGx Testing vs Acute Pain - Delayed PGx Testing: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Acute Pain - Immediate PGx Testing vs Acute Pain - Delayed PGx Testing: deaths from any cause. Trial comparisons, record NCT05966129-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05966129-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.00125 | 0.00022 | 0.00704 | wilson | |
| Risk in group 2 | 0.0025 | 0.000685 | 0.00906 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00125 | -0.00789 | 0.00482 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.5 | 0.0454 | 5.5 | log | |
| Odds ratio, group 1 over group 2 | 0.499 | 0.0452 | 5.52 | log | |
| Number needed to treat, for one fewer death from any cause on Acute Pain - Immediate PGx Testing than on Acute Pain - Delayed PGx Testing | 801 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Acute Pain - Immediate PGx Testing | Immediate genetic testing of CYP2D6 and clinical decisions support for pain management prescribing to the healthcare provider~Pharmacogenetic testing: Genetic testing of CYP2D6 and CYP2C19~Clinical decisions support: Prescribing recommendations to the provider based on the pharmacogenetic testing results | 1 | 801 | EG000 |
| Group 2 | Acute Pain - Delayed PGx Testing | Delayed genetic testing of CYP2D6 and return of results after the conclusion of the 6-month follow-up period~Pharmacogenetic testing: Genetic testing of CYP2D6 and CYP2C19 | 2 | 801 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
Source ClinicalTrials.gov
Trial
- Title
- A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Acute Pain Trial)
- NCT number
- NCT05966129
- Phases
- NA
- Conditions
- Acute Pain
- Interventions
- Pharmacogenetic testing, Clinical decisions support
- Lead sponsor
- Duke University
- Results first posted
- 2025-06-05
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05966129?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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