Comparison · NCT05966155-64699a87
Depression - Immediate PGx Testing (Modified Intent to Treat, mITT) vs Depression - Delayed PGx Testing (Modified Intent to Treat, mITT): Number of Participants With Depression Remission as Measured by the Patient Health Questionnaire (PHQ-8)
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Depression - Immediate PGx Testing (Modified Intent to Treat, mITT) vs Depression - Delayed PGx Testing (Modified Intent to Treat, mITT): Number of Participants With Depression Remission as Measured by the Patient Health Questionnaire (PHQ-8). Trial comparisons, record NCT05966155-64699a87. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05966155-64699a87
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.299 | 0.251 | 0.351 | wilson | |
| Risk in group 2 | 0.21 | 0.169 | 0.259 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0884 | 0.0201 | 0.155 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.42 | 1.08 | 1.87 | log | |
| Odds ratio, group 1 over group 2 | 1.6 | 1.11 | 2.3 | log | |
Number needed to treat, for one more participant with the outcome on Depression - Immediate PGx Testing (Modified Intent to Treat, mITT) than on Depression - Delayed PGx Testing (Modified Intent to Treat, mITT) | 11.3 | 6.43 | 49.7 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Depression - Immediate PGx Testing (Modified Intent to Treat, mITT) | Immediate genetic testing of CYP2D6 and CYP2C19 and clinical decisions support for antidepressant prescribing to the healthcare provider | 95 | 318 | OG000 |
| Group 2 | Depression - Delayed PGx Testing (Modified Intent to Treat, mITT) | Delayed genetic testing of CYP2D6 and CYP2C19 and return of results after the conclusion of the 6-month follow-up period | 65 | 309 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Depression Remission as Measured by the Patient Health Questionnaire (PHQ-8)
- Description
- The PHQ-8 scores range from 0 to 24 and remission is defined as having a PHQ-8 score of ≤ 4.
- Time frame
- 6 months
- Population
Modified intent to treat (mITT) population consisting of participants with a CYP2C19 poor, rapid, or ultra-rapid metabolizer phenotype or a CYP2D6 poor or ultra-rapid metabolizer phenotype. All mITT participants with a completed PHQ-8 survey at 6 months are include. Participants with an incomplete PHQ-8 survey are excluded.
Source ClinicalTrials.gov
Trial
- Title
- A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Depression Trial)
- NCT number
- NCT05966155
- Phases
- NA
- Conditions
- Depression
- Interventions
- Pharmacogenetic testing, Clinical decisions support
- Lead sponsor
- Duke University
- Results first posted
- 2025-06-29
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05966155?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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