Comparison · NCT05966155-deaths
Depression - Immediate PGx Testing vs Depression - Delayed PGx Testing: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Depression - Immediate PGx Testing vs Depression - Delayed PGx Testing: deaths from any cause. Trial comparisons, record NCT05966155-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT05966155-deaths
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.00138 | 0.000243 | 0.00775 | wilson | |
| Risk in group 2 | 0.00273 | 0.000749 | 0.00989 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00135 | -0.00861 | 0.00532 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.504 | 0.0458 | 5.55 | log | |
| Odds ratio, group 1 over group 2 | 0.503 | 0.0456 | 5.56 | log | |
| Number needed to treat, for one fewer death from any cause on Depression - Immediate PGx Testing than on Depression - Delayed PGx Testing | 739 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Depression - Immediate PGx Testing | Immediate genetic testing of CYP2D6 and CYP2C19 and clinical decisions support for antidepressant prescribing to the healthcare provider | 1 | 727 | EG000 |
| Group 2 | Depression - Delayed PGx Testing | Delayed genetic testing of CYP2D6 and CYP2C19 and return of results after the conclusion of the 6-month follow-up period | 2 | 733 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
Source ClinicalTrials.gov
Trial
- Title
- A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Depression Trial)
- NCT number
- NCT05966155
- Phases
- NA
- Conditions
- Depression
- Interventions
- Pharmacogenetic testing, Clinical decisions support
- Lead sponsor
- Duke University
- Results first posted
- 2025-06-29
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT05966155?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
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