Comparison · NCT06042855-84ad37de
Arm G - Metformin vs Arm G - Placebo: Number of Participants With Hospitalization, Urgent Care, Emergency Room Visit, or Death
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Arm G - Metformin vs Arm G - Placebo: Number of Participants With Hospitalization, Urgent Care, Emergency Room Visit, or Death. Trial comparisons, record NCT06042855-84ad37de. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT06042855-84ad37de
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0374 | 0.0288 | 0.0485 | wilson | |
| Risk in group 2 | 0.0317 | 0.024 | 0.0416 | wilson | |
| Risk difference, group 1 minus group 2 | 0.00577 | -0.0074 | 0.0192 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.18 | 0.808 | 1.73 | log | |
| Odds ratio, group 1 over group 2 | 1.19 | 0.802 | 1.76 | log | |
| Number needed to treat, for one more participant with the outcome on Arm G - Metformin than on Arm G - Placebo | 173 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Arm G - Metformin | Metformin IR tablets will be self-administered orally according to the following dosing schedule:~* 500 mg on Day 1;~* 500 mg in the morning and 500 mg in the evening on Day 2 through Day 5; and~* 500 mg in the morning and 2 x 500 mg (a total of 1000 mg) in the evening on Day 6 through Day 14.~Metformin: Metformin IR tablets contain the active metformin hydrochloride and inactive ingredients including povidone and magnesium stearate. Commercially available metformin 500 mg tablets will be provided. | 54 | 1,443 | OG000 |
| Group 2 | Arm G - Placebo | Placebo - appearance and size matched to active study drug.~Placebo will be self-administered orally by each participant, with number of tablets matched to active study drug dosing.~Placebo: Each study arm will contain a placebo comparator. Placebo will look similar to study drug and will be administered via the same route of administration and dose. However, placebo will be an inactive substance, containing no study drug. | 49 | 1,548 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Hospitalization, Urgent Care, Emergency Room Visit, or Death
- Description
- Time frame
- Up to 28 days
- Population
Source ClinicalTrials.gov
Trial
- Title
- ACTIV-6: COVID-19 Study of Repurposed Medications - Arm G (Metformin)
- NCT number
- NCT06042855
- Phases
- PHASE3
- Conditions
- Covid19
- Interventions
- Placebo, Metformin
- Lead sponsor
- Susanna Naggie, MD
- Results first posted
- 2025-07-20
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT06042855?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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