Comparison · NCT06291831-ce2a55f2
Treated With Paxlovid vs Not Treated With Paxlovid: Number of Participants With at Least 1 Pre-existing Comorbidities
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Treated With Paxlovid vs Not Treated With Paxlovid: Number of Participants With at Least 1 Pre-existing Comorbidities. Trial comparisons, record NCT06291831-ce2a55f2. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT06291831-ce2a55f2
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.852 | 0.836 | 0.867 | wilson | |
| Risk in group 2 | 0.915 | 0.896 | 0.93 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0621 | -0.0847 | -0.0381 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.932 | 0.908 | 0.957 | log | |
| Odds ratio, group 1 over group 2 | 0.54 | 0.419 | 0.695 | log | |
| Number needed to treat, for one fewer participant with the outcome on Treated With Paxlovid than on Not Treated With Paxlovid | 16.1 | 11.8 | 26.2 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Treated With Paxlovid | Participants who were diagnosed with COVID-19 and accepted offer for treatment with Paxlovid (nirmatrelvir, ritonavir) treatment in real world setting. No intervention was administered under this study. | 1,709 | 2,005 | OG000 |
| Group 2 | Not Treated With Paxlovid | Participants who were diagnosed with COVID-19 and declined offer for treatment with Paxlovid (nirmatrelvir, ritonavir) treatment. This reporting arm served as control group. | 920 | 1,006 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Participants With at Least 1 Pre-existing Comorbidities
- Description
Pre-existing comorbidities included: asthma, emphysema, chronic obstructive pulmonary disease (COPD), hypertension, diabetes, obesity, cerebrovascular disease, neurological disease, chronic kidney disease, chronic liver disease, malignancy. Baseline was defined as one year before the index date. Index date was Paxlovid prescription written date or dispense date; if neither of them were available, the COVID-19 diagnosis date was used as the index date.
- Time frame
- Baseline; from available retrospective data evaluated during 2 months of this study
- Population
- Analysis population included all eligible participants whose data were included and observed in this study.
Source ClinicalTrials.gov
Trial
- Title
- A Study to Learn About the Use of Paxlovid in Patients With COVID-19 in the Kingdom of Bahrain.
- NCT number
- NCT06291831
- Phases
- Conditions
- COVID-19
- Interventions
- nirmatrelvir, ritonavir, Controls
- Lead sponsor
- Pfizer
- Results first posted
- 2025-08-19
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT06291831?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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