Comparison · NCT06634797-4e9d6540
Sequence 1: mRNA-1273.712 Then Placebo vs Sequence 2: Placebo Then mRNA-1273.712: Number of Participants With Elevated cTnI Level at Day 1 (Baseline)
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Sequence 1: mRNA-1273.712 Then Placebo vs Sequence 2: Placebo Then mRNA-1273.712: Number of Participants With Elevated cTnI Level at Day 1 (Baseline). Trial comparisons, record NCT06634797-4e9d6540. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT06634797-4e9d6540
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.00407 | 0.00112 | 0.0147 | wilson | |
| Risk in group 2 | 0.0102 | 0.00438 | 0.0237 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00615 | -0.02 | 0.006 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.398 | 0.0777 | 2.04 | log | |
| Odds ratio, group 1 over group 2 | 0.396 | 0.0764 | 2.05 | log | |
| Number needed to treat, for one fewer participant with the outcome on Sequence 1: mRNA-1273.712 Then Placebo than on Sequence 2: Placebo Then mRNA-1273.712 | 163 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Sequence 1: mRNA-1273.712 Then Placebo | Participants received mRNA-1273.712 as an intramuscular (IM) injection on Day 1 of the study. Participants then received placebo matched to mRNA-1273.712 as an IM injection on Day 29 of the study. | 2 | 491 | OG000 |
| Group 2 | Sequence 2: Placebo Then mRNA-1273.712 | Participants received placebo matched to mRNA-1273.712 as an IM injection on Day 1 of the study. Participants then received mRNA-1273.712 as an IM injection on Day 29 of the study. | 5 | 489 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Elevated cTnI Level at Day 1 (Baseline)
- Description
- Elevated cTnI was defined as \>53.53 pg/mL in males and \>38.64 pg/mL in females.
- Time frame
- Pre-injection 1: Day 1
- Population
Evaluable Set: All randomized participants who received at least 1 study injection who had no major protocol deviations or conditions/medications that impacted critical or key analysis data. The 'number of participants analysed' includes the number of participants with non-missing cTnI at Day 1.
Source ClinicalTrials.gov
Trial
- Title
- A Study to Investigate Cardiac Troponin Levels After mRNA-1273.712 Vaccine in Participants 12 Through 30 Years of Age
- NCT number
- NCT06634797
- Phases
- PHASE4
- Conditions
- Healthy Volunteers
- Interventions
- mRNA-1273.712, Placebo
- Lead sponsor
- ModernaTX, Inc.
- Results first posted
- 2026-02-04
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT06634797?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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