Disease · MONDO_0000004
Trials17
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.
1 to 17 of 17
Download this page as JSON| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT00915343 | Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency | Phase 2/3 | 64 | 2015-07-20 | Adrenal Insufficiency | HYDROCORTISONE | Its record names the disease | ClinicalTrials.gov |
| NCT00462644 | Evaluation of Etomidate on Adrenal Function in Trauma Patients | Not applicable | 30 | 2009-11-11 | Adrenal Insufficiency | ETOMIDATE, FENTANYL, MIDAZOLAM | Its record names the disease | ClinicalTrials.gov |
| NCT02720952 | Treatment of Adrenal Insufficiency in Children | Phase 3 | 24 | 2017-04-11 | Adrenal Insufficiency | HYDROCORTISONE | Its record names the disease | ClinicalTrials.gov |
| NCT02733367 | Extension Study for Patients Entered Into Study Infacort 003 | Phase 3 | 18 | 2019-09-13 | Adrenal Insufficiency | HYDROCORTISONE | Its record names the disease | ClinicalTrials.gov |
| NCT04621565 | Hydrocortisone Use During Peri-operation for Pituitary Adenomas | Not applicable | 436 | Pituitary Adenoma, Adrenal Insufficiency, Surgery | HYDROCORTISONE, SODIUM CHLORIDE | Its record names the disease | ClinicalTrials.gov | |
| NCT00862381 | Hydrocortisone Use After Etomidate in Intensive Care | Phase 3 | 106 | Patient Admitted in Reanimation | HYDROCORTISONE | Its record names the disease | ClinicalTrials.gov | |
| NCT07558135 | The ARISE Trial Compares Whether Giving Routine Steroid Replacement or Using Targeted Blood Tests to Guide Replacement Better Protects Certain Patients From Adrenal Insufficiency After the Removal of a Diseased Adrenal Gland. | Not applicable | 96 | Adrenal Gland Disease | HYDROCORTISONE | Its record names the disease | ClinicalTrials.gov | |
| NCT02277587 | Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) | Phase 4 | 89 | Primary Adrenal Insufficiency, Secondary Adrenal Insufficiency | HYDROCORTISONE | Its record names the disease | ClinicalTrials.gov | |
| NCT03282487 | Optimising Steroid Replacement in Patients With Adrenal Insufficiency | Phase 4 | 60 | Adrenal Insufficiency | HYDROCORTISONE | Its record names the disease | ClinicalTrials.gov | |
| NCT05222152 | Chronocort Versus Plenadren Replacement Therapy in Adults With Adrenal Insufficiency | Phase 2 | 58 | Primary Adrenal Insufficiency | HYDROCORTISONE | Its record names the disease | ClinicalTrials.gov | |
| NCT00657306 | Adrenal Insufficiency in Cirrhotics With Ascites. Effects of Hydrocortisone on Renal and Haemodynamic Function | Phase 2 | 50 | Cirrhosis With Ascites | HYDROCORTISONE | Its record names the disease | ClinicalTrials.gov | |
| NCT03936517 | Safety and Efficacy of Prednisolone in Adrenal Insufficiency Disease (PRED-AID Study) | Phase 3 | 44 | Adrenal Insufficiency | HYDROCORTISONE, PREDNISOLONE | Its record names the disease | ClinicalTrials.gov | |
| NCT03258619 | Natriuresis as a Predictor of the Haemodynamic Response to Steroid Replacement Therapy in Patients in Septic Shock | 40 | Septic Shock | HYDROCORTISONE HEMISUCCINATE | Its record names the disease | ClinicalTrials.gov | ||
| NCT02282150 | Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism | Phase 4 | 30 | Adrenal Insufficiency | HYDROCORTISONE | Its record names the disease | ClinicalTrials.gov | |
| NCT00688987 | The Hypothalamic-Pituitary-Adrenal (HPA) Axis as an Effector System in Weight Regulation | Not applicable | 24 | Obesity, Addison's Disease | HYDROCORTISONE | Its record names the disease | ClinicalTrials.gov | |
| NCT01450930 | Pharmacokinetics of Hydrocortisone After Subcutaneous Administration in Chronic Adrenal Insufficiency | Phase 2 | 12 | Primary Adrenal Insufficiency | HYDROCORTISONE | Its record names the disease | ClinicalTrials.gov | |
| NCT02152553 | Biomarker(s) for Glucocorticoids | Not applicable | 11 | Addison Disease | HYDROCORTISONE | Its record names the disease | ClinicalTrials.gov |
diseases-2026-09-18-0.1.0
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this list from software.
Twenty rows a page, as JSON. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0000004/trials