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Disease · MONDO_0005097

Comparisons in its trials18

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
Afatinib vs Erlotinib: Number of Participants With Disease Control According to RECIST 1.1201 of 398157 of 397795NCT01523587Trial comparisons
Afatinib vs Erlotinib: Number of Participants With Objective Response According to RECIST 1.122 of 39811 of 397795NCT01523587Trial comparisons
Afatinib vs Erlotinib: deaths from any cause77 of 39271 of 395787NCT01523587Trial comparisons
Afatinib vs Erlotinib: serious adverse events174 of 392175 of 395787NCT01523587Trial comparisons
Nivolumab + Ipilimumab vs Nivolumab: deaths from any cause92 of 125105 of 127252NCT02785952Trial comparisons
Nivolumab + Ipilimumab vs Nivolumab: serious adverse events78 of 12458 of 123247NCT02785952Trial comparisons
Second-line Afatinib Treatment Group vs Second-line Chemotherapy Treatment Group: Number of Patients With Severe Immune-related Adverse Events (irAEs) of Specific Interest During Second-line Treatment6 of 990 of 101200NCT04552535Trial comparisons
Arm I & Arm III (Initial Treatment and Retreatment With MEDI4736) vs Arm II (Docetaxel - Closed to Accrual 4/2015): deaths from any cause58 of 6826 of 3098NCT02766335Trial comparisons
Arm I & Arm III (Initial Treatment and Retreatment With MEDI4736) vs Arm II (Docetaxel - Closed to Accrual 4/2015): serious adverse events27 of 683 of 3098NCT02766335Trial comparisons
A: Erlotinib vs B: Docetaxel: deaths from any cause7 of 383 of 4179NCT01652469Trial comparisons
A: Erlotinib vs B: Docetaxel: serious adverse events7 of 3819 of 4179NCT01652469Trial comparisons
Palbociclib vs Docetaxel: deaths from any cause28 of 3210 of 1042NCT02785939Trial comparisons
Palbociclib vs Docetaxel: serious adverse events14 of 320 of 1042NCT02785939Trial comparisons
AZD4547 vs Docetaxel: deaths from any cause25 of 279 of 936NCT02965378Trial comparisons
AZD4547 vs Docetaxel: serious adverse events7 of 271 of 936NCT02965378Trial comparisons
Afatinib 40 mg + Pembrolizumab 200 mg vs Afatinib 30 mg + Pembrolizumab 200 mg: deaths from any cause10 of 1210 of 1224NCT03157089Trial comparisons
Afatinib 40 mg + Pembrolizumab 200 mg vs Afatinib 30 mg + Pembrolizumab 200 mg: serious adverse events4 of 129 of 1224NCT03157089Trial comparisons
Afatinib 40 mg + Pembrolizumab 200 mg vs Afatinib 30 mg + Pembrolizumab 200 mg: Duration of Objective Response (DOR)2 of 21 of 13NCT03157089Trial comparisons

diseases-2026-09-18-0.1.0

Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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