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Disease · MONDO_0015925

Comparisons in its trials28

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
Inhaled Treprostinil vs Placebo: Incidence of Clinical Worsening37 of 16354 of 163326NCT02630316Trial comparisons
Active Inhaled Treprostinil vs Placebo: deaths from any cause10 of 16312 of 163326NCT02630316Trial comparisons
Active Inhaled Treprostinil vs Placebo: serious adverse events38 of 16342 of 163326NCT02630316Trial comparisons
Pirfenidone vs Placebo: Number of Participants With Treatment-emergent Adverse Events (TEAEs)120 of 127101 of 124251NCT03099187Trial comparisons
Cylophosphamide vs Placebo: serious adverse events5 of 795 of 79158NCT00004563Trial comparisons
Mycophenolate Arm vs Cyclophosphamide Arm: serious adverse events27 of 6922 of 73142NCT00883129Trial comparisons
Pirfenidone vs Placebo: Hospitalization for Respiratory Cause2 of 635 of 60123NCT02808871Trial comparisons
Pirfenidone vs Placebo: Number of Participants Who Developed Any Element of the Composite Endpoint7 of 639 of 60123NCT02808871Trial comparisons
Pirfenidone vs Placebo: All-cause Mortality2 of 633 of 60123NCT02808871Trial comparisons
Pirfenidone vs Placebo: Number of Participants With Progressive Disease16 of 6319 of 60123NCT02808871Trial comparisons
Pirfenidone vs Placebo: All Cause Hospitalization7 of 637 of 60123NCT02808871Trial comparisons
Pirfenidone vs Placebo: Acute Exacerbations Requiring Hospitalization1 of 632 of 60123NCT02808871Trial comparisons
Pirfenidone vs Placebo: deaths from any cause2 of 633 of 60123NCT02808871Trial comparisons
Pirfenidone vs Placebo: Number of Participants With FVC Decline From Baseline of 10% or Greater5 of 637 of 60123NCT02808871Trial comparisons
Pirfenidone vs Placebo: Treatment-emergent/Treatment-related SAEs1 of 620 of 60122NCT02808871Trial comparisons
Pirfenidone vs Placebo: Treatment-emergent Death or Transplant2 of 624 of 60122NCT02808871Trial comparisons
Pirfenidone vs Placebo: Treatment-emergent/Treatment-related AEs27 of 6218 of 60122NCT02808871Trial comparisons
Pirfenidone vs Placebo: AEs Leading to Early Discontinuation of Study Treatment15 of 626 of 60122NCT02808871Trial comparisons
Pirfenidone vs Placebo: Treatment-emergent Serious Adverse Events (SAEs)9 of 628 of 60122NCT02808871Trial comparisons
Pirfenidone vs Placebo: Treatment-emergent Adverse Events (AEs)62 of 6256 of 60122NCT02808871Trial comparisons

diseases-2026-09-18-0.1.0

Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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