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MDC1: mediator of DNA damage checkpoint 1
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Gene · 9656

Papers2,704

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 2,704

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TitleJournalYearPMIDFound bySource
MCPH1 and DNA Damage Response Pathway Genes as Candidate Susceptibility Loci in Hereditary Breast Cancer.Diagnostics (Basel)202642793752PubTator, text miningPubMed
A germline KDM3C polymorphism impairs DNA repair and sensitizes to chemoradiotherapy.medRxiv202642732193PubTator, text miningPubMed
Dynamic chromatin tethering of MDC1 regulates genome stability.Nucleic Acids Res202642703974PubTator, text miningPubMed
Impact of Infection-Related Immune Responses on ANCA-Associated Vasculitis in Finns: A Mendelian Randomization Study.Genet Res (Camb)202642634225PubTator, text miningPubMed
Targeting THOC2-Mediated mRNA Export Induces PARP Inhibitor Vulnerability in DNA Repair-Competent Hepatocellular Carcinoma.Int J Biol Sci202642328459PubTator, text miningPubMed
Lactate-Associated Gene Signatures as Predictors: A Comprehensive Analysis of Immune Profiles in Sepsis.J Intensive Care Med202642286943PubTator, text miningPubMed
MDC1 promotes nuclear localization of Beclin-1 and supports its role in ATM pathway in response to oxidative stress.Eur J Cell Biol202642013721PubTator, text miningPubMed
RNF126 and BRAP safeguard genome integrity after DNA damage in late mitosis.Cell Rep202641996237PubTator, text miningPubMed
Whole-exome sequencing unveils novel potential gene mutations involved in primary renal small cell carcinoma.Oncol Lett202641969585PubTator, text miningPubMed
Computational phosphoproteomic insights into predominant BRAF phosphosites and associated regulatory networks in cancer.Biochim Biophys Acta Proteins Proteom202641936939PubTator, text miningPubMed
Differential sensitivity of MCPH1- and BRCA2-deficient cancer cells to PARP-1 inhibition.PLoS One202641931484PubTator, text miningPubMed
CBX2 phase-separation contributes to homologous recombination repair and drug resistance in ovarian cancer.Cell Death Dis202641888115PubTator, text miningPubMed
The EHMT2-MBLAC2 axis suppresses ribosomal DNA transcription in response to nucleolar DNA damage.Cell Death Dis202641851073PubTator, text miningPubMed
ISGylation of γH2AX retains MDC1 and facilitates homologous recombination repair causing radioresistance in esophageal adenocarcinoma.J Biol Chem202641812883PubTator, text miningPubMed
Next Generation DNA Damage Response Inhibitors: Harnessing Nanocarriers and Tumor Microenvironment for Precision Cancer Therapy.Oncol Res202641799521PubTator, text miningPubMed
Novel driver gene MDC1 confers homologous recombination repair deficiency and genomic instability in chemoresistant relapsing ovarian cancer.J Transl Med202641792798PubTator, text miningPubMed
The enigma of nuclear FMRP: facts and myths.Front Cell Dev Biol202641768999PubTator, text miningPubMed
Dysregulation of the DNA damage response by phosphorothioate antisense oligonucleotides.Nat Commun202641760661PubTator, text miningPubMed
Tankyrases and Their Binding Proteins: Origins of Their Roles in Diverse Cellular Pathways.Cells202641744791PubTator, text miningPubMed
Anti-myeloma activity of the CXCR4 antagonist WZ811.J Mol Med (Berl)202641701357PubTator, text miningPubMed

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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