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Paper · 100225

A complete immunoglobulin gene is created by somatic recombination.

Brack C and 3 others. Cell, 1978. Cited by 489 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A complete immunoglobulin gene is created by somatic recombination. Papers, record 100225. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/100225

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
A complete immunoglobulin gene is created by somatic recombination.
PubMed
Journal
Cell
PubMed
Year
1978
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
489
iCite
Relative citation ratio, by iCite
8.32
iCite
Revised in PubMed
2019-07-05
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Brack CC
2Hirama MM
3Lenhard-Schuller RR
4Tonegawa SS

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Binding Sites, AntibodyMajor topic
GenesMajor topic
Immunoglobulin Constant RegionsMajor topic
Immunoglobulin Light ChainsMajor topic
Immunoglobulin Variable RegionMajor topic
Immunoglobulin lambda-ChainsMajor topic
ImmunoglobulinsMajor topic
Recombination, GeneticMajor topic
Animals
DNA, Recombinant
Embryo, Mammalian
Genetic Linkage
Mice
Myeloma Proteins
Plasma Cells

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in15,055,594That great time in Basel.https://conductscience.org/library/papers/15055594

Source PubMed

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by195

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 489 citations.

PMIDTitleJournalYearIn PapersSource
42,162,238ANARCII enables alignment-free antigen receptor numbering using a generalised language model.Commun Biol2026https://conductscience.org/library/papers/42162238PubMed
41,516,058The Role of Active Site Hydrophobic Interactions in Facilitating Catalysis in Human Terminal Deoxynucleotidyl Transferase.Int J Mol Sci2025https://conductscience.org/library/papers/41516058PubMed
39,763,954A personalized multi-platform assessment of somatic mosaicism in the human frontal cortex.bioRxiv2025https://conductscience.org/library/papers/39763954PubMed
39,584,990A Brief Chronicle of Antibody Research and Technological Advances.Antibodies (Basel)2024https://conductscience.org/library/papers/39584990PubMed
39,141,734Parsing digital or analog TCR performance through piconewton forces.Sci Adv2024https://conductscience.org/library/papers/39141734PubMed
38,967,746Non B Cell-Derived Immunoglobulin, A Brighter Horizon for the Future.Adv Exp Med Biol2024https://conductscience.org/library/papers/38967746PubMed
38,482,007Investigating the ability of deep learning-based structure prediction to extrapolate and/or enrich the set of antibody CDR canonical forms.Front Immunol2024https://conductscience.org/library/papers/38482007PubMed
37,624,867Germline-encoded specificities and the predictability of the B cell response.PLoS Pathog2023https://conductscience.org/library/papers/37624867PubMed
37,326,969Unconventional T cells in chronic disease and as targets of therapy.Clin Exp Immunol2023https://conductscience.org/library/papers/37326969PubMed
37,021,521Regulatory mechanisms of GCN5 in osteogenic differentiation of MSCs in periodontitis.Clin Exp Dent Res2023https://conductscience.org/library/papers/37021521PubMed

1 to 10 of 195

See all 195 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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