Paper · 10433902

Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development.

Lin X and 3 others. Development, 1999. Cited by 298 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development. Papers, record 10433902. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/10433902

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development.; PubMed
Journal: Development; PubMed
Year: 1999; PubMed
Publication types: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/10433902/; PubMed
DOI: https://doi.org/10.1242/dev.126.17.3715; PubMed
The journal: https://conductscience.org/library/journal-index/8701744; PubMed
Citations, by iCite: 298; iCite
Relative citation ratio, by iCite: 5.55; iCite
Revised in PubMed: 2022-02-15; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Lin X	X
2	Buff EM	E M
3	Perrimon N	N
4	Michelson AM	A M

Source PubMed

Topics18

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Drosophila	Major topic
Drosophila Proteins	Major topic
Fibroblast Growth Factors	Major topic
Heparan Sulfate Proteoglycans	Major topic
Protein-Tyrosine Kinases	Major topic
Receptors, Fibroblast Growth Factor	Major topic
Amidohydrolases
Animals
Gene Expression
Genes, Insect
Insect Proteins
Mesoderm
Mitogen-Activated Protein Kinases
Mutation
Phenotype
Signal Transduction
Sulfotransferases
Trachea

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References0

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

None in this release.

Cited by104

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 298 citations.

PMID	Title	Journal	Year	In Papers	Source
39,729,990	Heparan sulfate regulates the fate decisions of human pluripotent stem cells.	Stem Cell Reports	2025	https://conductscience.org/library/papers/39729990	PubMed
37,750,089	FGFR families: biological functions and therapeutic interventions in tumors.	MedComm (2020)	2023	https://conductscience.org/library/papers/37750089	PubMed
37,016,295	The genetic basis of wing spots in Pieris canidia butterflies.	BMC Genomics	2023	https://conductscience.org/library/papers/37016295	PubMed
36,699,460	Regulation of autophagy, lipid metabolism, and neurodegenerative pathology by heparan sulfate proteoglycans.	Front Genet	2022	https://conductscience.org/library/papers/36699460	PubMed
36,503,154	Neuronal expression of ndst3 in early zebrafish development is responsive to Wnt signaling manipulation.	Gene Expr Patterns	2023	https://conductscience.org/library/papers/36503154	PubMed
35,648,312	Therapeutic Potential of Skin Stem Cells and Cells of Skin Origin: Effects of Botanical Drugs Derived from Traditional Medicine.	Stem Cell Rev Rep	2022	https://conductscience.org/library/papers/35648312	PubMed
35,319,900	Coreceptor functions of cell surface heparan sulfate proteoglycans.	Am J Physiol Cell Physiol	2022	https://conductscience.org/library/papers/35319900	PubMed
34,124,035	In vivo Functional Genomics for Undiagnosed Patients: The Impact of Small GTPases Signaling Dysregulation at Pan-Embryo Developmental Scale.	Front Cell Dev Biol	2021	https://conductscience.org/library/papers/34124035	PubMed
32,664,575	Cerebellar Morphology and Behavioral Profiles in Mice Lacking Heparan Sulfate Ndst Gene Function.	J Dev Biol	2020	https://conductscience.org/library/papers/32664575	PubMed
32,001,716	Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy.	Nat Commun	2020	https://conductscience.org/library/papers/32001716	PubMed

1 to 10 of 104

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Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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